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The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis
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The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis
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Journal Article
The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis
2019
Overview
Background
Studies investigating the role of hyperoxia in critically ill patients have reported conflicting results. We did this analysis to reveal the effect of hyperoxia in the patients admitted to the intensive care unit (ICU).
Methods
Electronic databases were searched for all the studies exploring the role of hyperoxia in adult patients admitted to ICU. The primary outcome was mortality. Random-effect model was used for quantitative synthesis of the adjusted odds ratio (aOR).
Results
We identified 24 trials in our final analysis. Statistical heterogeneity was found between hyperoxia and normoxia groups in patients with mechanical ventilation (I
2
= 92%,
P
< 0.01), cardiac arrest(I
2
= 63%,
P
= 0.01), traumatic brain injury (I
2
= 85%,
P
< 0.01) and post cardiac surgery (I
2
= 80%,
P
= 0.03). Compared with normoxia, hyperoxia was associated with higher mortality in overall patients (OR 1.22, 95% CI 1.12~1.33), as well as in the subgroups of cardiac arrest (OR 1.30, 95% CI 1.08~1.57) and extracorporeal life support (ELS) (OR 1.44, 95% CI 1.03~2.02).
Conclusions
Hyperoxia would lead to higher mortality in critically ill patients especially in the patients with cardiac arrest and ELS.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Brain Injuries, Traumatic - mortality
/ Cardiac Surgical Procedures - statistics & numerical data
/ China
/ Critical Illness - mortality
/ Extracorporeal Membrane Oxygenation - statistics & numerical data
/ Heart
/ Humans
/ Medicine
/ Oxygen Inhalation Therapy - adverse effects
/ Pneumology/Respiratory System
/ Respiration, Artificial - statistics & numerical data
/ Studies
/ Surgery
