Journal Article

Pilot randomized trial of short-term changes in inflammation and lipid levels during and after aspirin and pravastatin therapy

Sjaarda, Lindsey A., Hill, Micah J., Plowden, Torie C., Flannagan, Kerry S., Mumford, Sunni L., Zolton, Jessica R., Andriessen, Victoria C., Perkins, Neil J., Connell, Matthew T., Radoc, Jeannie G., Schisterman, Enrique F.

2019

Overview

Background Inflammation and elevated blood lipids are associated with infertility. Aspirin and statin therapy may improve infertility treatment outcomes among overweight and obese women with systemic inflammation, but little is known about the short-term effects of statins in this population. We conducted a pilot study of aspirin, pravastatin, or combined treatment among a group of overweight and obese, reproductive-aged women. Our goal was to characterize short-term changes in inflammatory and lipid biomarkers during and after treatment. Methods In this open-label trial, women aged 18–40 years with a body mass index ≥25 kg/m 2 were randomized to receive either 162 mg aspirin, 40 mg pravastatin, or both. The study medication was taken daily for 2 weeks, and participants were then followed for a two-week washout period. Participants provided blood samples at baseline, after the intervention period, and after the washout period. The outcomes were changes in biomarkers of inflammation and lipids measured in blood components at each timepoint. Results Nine, 8, and 8 women were randomized to the aspirin, pravastatin, and combined arms, respectively. Analyses were conducted among 8, 7, and 7 women in the aspirin, pravastatin, and combined arms for whom biomarker data was available at baseline. High-sensitivity C-reactive protein (hsCRP) levels were lower after treatment in all arms and continued to decrease after washout in the pravastatin and combined arms. Results were consistent between the whole sample and women with baseline hsCRP between 2 and 10 mg/L. Low-density lipoprotein (LDL) cholesterol was lower after treatment in the pravastatin and combined arms and rose slightly after washout. Conclusions Our results provide preliminary evidence that short-term aspirin and pravastatin therapy reduces hsCRP and LDL cholesterol among overweight and obese women of reproductive age, including those with low-grade inflammation. Because of these short-term effects, these drugs may improve infertility treatment outcomes in this population, which we will assess in a future randomized trial.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adolescent / Adult / Anti-Inflammatory Agents, Non-Steroidal - administration & dosage / Anticholesteremic Agents - administration & dosage / Antilipemic agents / Aspirin / Aspirin - administration & dosage / Biological markers / Biomarkers / Biomarkers - blood / Blood lipids / Body mass index / C-reactive protein / C-Reactive Protein - analysis / Cholesterol / Cholesterol, LDL - blood / Clinical trials / Dosage and administration / Drug therapy / Female / Female infertility / Humans / Infertility / Infertility treatment / Inflammation / Inflammation - blood / Inflammation - drug therapy / Inflammation - pathology / Labels / Lipids / Lipids - blood / Low density lipoproteins / Maternal and Child Health / Measurement / Medicine / Medicine & Public Health / Obesity / Overweight / Overweight and obesity / Patient outcomes / Pilot Projects / Pravastatin / Pravastatin - administration & dosage / Public Health / Reproductive health / Reproductive Medicine / Statins / Trans fatty acids / Treatment Outcome / Womens health / Young Adult