Asset Details
Do you wish to reserve the book?
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort
Do you wish to request the book?
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort
2016
Overview
Background
Previous studies have developed models predicting methylation age from DNA methylation in blood and other tissues (epigenetic clock) and suggested the difference between DNA methylation and chronological ages as a marker of healthy aging. The goal of this study was to confirm and expand such observations by investigating whether different concepts of the epigenetic clocks in a population-based cohort are associated with cancer, cardiovascular, and all-cause mortality.
Results
DNA methylation age was estimated in a cohort of 1863 older people, and the difference between age predicted by DNA methylation and chronological age (Δ
age
) was calculated. A case-cohort design and weighted proportional Cox hazard models were used to estimate associations of Δ
age
with cancer, cardiovascular, and all-cause mortality. Hazard ratios for Δ
age
(per 5 years) calculated using the epigenetic clock developed by Horvath were 1.23 (95 % CI 1.10–1.38) for all-cause mortality, 1.22 (95 % CI 1.03–1.45) for cancer mortality, and 1.19 (95 % CI 0.98–1.43) for cardiovascular mortality after adjustment for batch effects, age, sex, educational level, history of chronic diseases, hypertension, smoking status, body mass index, and leucocyte distribution. Associations were similar but weaker for Δ
age
calculated using the epigenetic clock developed by Hannum.
Conclusions
These results show that age acceleration in terms of the difference between age predicted by DNA methylation and chronological age is an independent predictor of all-cause and cause-specific mortality and may be useful as a general marker of healthy aging.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V
We currently cannot retrieve any items related to this title. Kindly check back at a later time.