Journal Article

EANM dosimetry committee recommendations for dosimetry of 177Lu-labelled somatostatin-receptor- and PSMA-targeting ligands

Sjögreen Gleisner, Katarina, Gnesin, Silvano, Cremonesi, Marta, Eberlein, Uta, Stokke, Caroline, Bernhardt, Peter, Chouin, Nicolas, Gabina, Pablo Minguez, Verburg, Frederik A., Cicone, Francesco, Konijnenberg, Mark, Gear, Jonathan

2022

Overview

The purpose of the EANM Dosimetry Committee is to provide recommendations and guidance to scientists and clinicians on patient-specific dosimetry. Radiopharmaceuticals labelled with lutetium-177 (177Lu) are increasingly used for therapeutic applications, in particular for the treatment of metastatic neuroendocrine tumours using ligands for somatostatin receptors and prostate adenocarcinoma with small-molecule PSMA-targeting ligands. This paper provides an overview of reported dosimetry data for these therapies and summarises current knowledge about radiation-induced side effects on normal tissues and dose-effect relationships for tumours. Dosimetry methods and data are summarised for kidneys, bone marrow, salivary glands, lacrimal glands, pituitary glands, tumours, and the skin in case of radiopharmaceutical extravasation. Where applicable, taking into account the present status of the field and recent evidence in the literature, guidance is provided. The purpose of these recommendations is to encourage the practice of patient-specific dosimetry in therapy with 177Lu-labelled compounds. The proposed methods should be within the scope of centres offering therapy with 177Lu-labelled ligands for somatostatin receptors or small-molecule PSMA.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V,Springer Verlag (Germany) [1976-....]
• Subject: Adenocarcinoma / Bioengineering / Bone marrow / bone-marrow dosimetry / Cardiology / Clinical Medicine / DNA-damage / Dose-response relationship / Dosimeters / Dosimetry / Extravasation / Guidelines / Humans / i-and-t / Imaging / Klinisk medicin / Lacrimal gland and Nasolacrimal duct / Life Sciences / Ligands / long-term / Lutetium / Lutetium - therapeutic use / Lutetium isotopes / Lutetium-177 / Male / Medical and Health Sciences / Medicin och hälsovetenskap / Medicine / Medicine & Public Health / membrane antigen / Metastases / Neuroendocrine / Neuroendocrine tumors / Nuclear Medicine / Nuclear Medicine & Medical Imaging / Oncology / Orthopedics / Patients / Pharmaceuticals / Pituitary / pre-therapeutic / Prostate / Prostate adenocarcinoma / Prostate cancer / Prostate-Specific Antigen / PSMA-targeting / Radiation effects / Radiation Injuries / radiation-dosimetry / Radiochemistry / Radioisotopes / Radiologi och bildbehandling / Radiology / Radiology and Medical Imaging / radionuclide-s values / Radiopharmaceuticals - adverse effects / Receptors / Receptors, Somatostatin / resistant prostate-cancer / Salivary gland / Salivary glands / Side effects / Somatostatin / Somatostatin receptors / Somatostatin-receptor ligands / Therapeutic applications / Tumors