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Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

by Intasan, Jintana , Fox, Lawrence , Kim, Jerome H. , Kroon, Eugène , Buranapraditkun, Supranee , Haddad, Elias K. , Robb, Merlin L. , Chomchey, Nitiya , Fullmer, Brandie A. , Pinyakorn, Suteeraporn , Muir, Roshell , Pagliuzza, Amélie , O’Connell, Robert , Gorelick, Robert J. , Colby, Donn J. , Trautmann, Lydie , Phanuphak, Nittaya , Chomont, Nicolas , Trichavaroj, Rapee , Michael, Nelson L. , Tovanabutra, Sodsai , Bolton, Diane L. , Rolland, Morgane , Takata, Hiroshi , Leyre, Louise , Ananworanich, Jintanat , Crowell, Trevor A. , Ubolyam, Sasiwimol

in Acute Disease / Antiretroviral agents / Antiretroviral drugs / Antiretroviral therapy / Antiretroviral Therapy, Highly Active / Biomedical and Life Sciences / Biomedicine / Brief Communication / Cancer Research / Dosage and administration / Drug therapy / Genetic aspects / Genotypes / Highly active antiretroviral therapy / HIV / HIV infections / HIV Infections - drug therapy / HIV Infections - genetics / HIV Infections - immunology / HIV-1 - genetics / Human immunodeficiency virus / Humans / Infectious Diseases / Interruption / Medical schools / Metabolic Diseases / Molecular Medicine / Neurosciences / Ribonucleic acid / RNA / RNA, Viral - genetics / Viral Load

2018

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Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

2018

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2018

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Journal Article

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

Intasan, Jintana,

Fox, Lawrence,

Kim, Jerome H.,

Kroon, Eugène,

Buranapraditkun, Supranee,

Haddad, Elias K.,

Robb, Merlin L.,

Chomchey, Nitiya,

Fullmer, Brandie A.,

Pinyakorn, Suteeraporn,

Muir, Roshell,

Pagliuzza, Amélie,

O’Connell, Robert,

Gorelick, Robert J.,

Colby, Donn J.,

Trautmann, Lydie,

Phanuphak, Nittaya,

Chomont, Nicolas,

Trichavaroj, Rapee,

Michael, Nelson L.,

Tovanabutra, Sodsai,

Bolton, Diane L.,

Rolland, Morgane,

Takata, Hiroshi,

Leyre, Louise,

Ananworanich, Jintanat,

Crowell, Trevor A.,

Ubolyam, Sasiwimol

2018

Overview

Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption. We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following analytical treatment interruption, indicating that additional strategies are required to control or eradicate HIV. Initiation of antiretroviral therapy in the first 2 weeks of HIV infection fails to prevent resurgence of virus after stopping treatment, indicating early establishment of a resilient viral reservoir.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

Acute Disease

/ Antiretroviral agents

/ Antiretroviral drugs

/ Antiretroviral therapy

/ Antiretroviral Therapy, Highly Active

/ Biomedical and Life Sciences

/ Biomedicine