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Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine

by Carey, Timothy , Muñoz-Alía, Miguel Á. , Baum, Alina , Graham, Melanie L. , Tesfay, Mulu , Sakuma, Toshie , Russell, Luke , Krotova, Karina , Russell, Stephen J. , Lathrum, Chase , Suksanpaisan, Lukkana , Zhang, Lianwen , Narjari, Riya , Lech, Patrycja , Ziegler, Christopher , Haselton, Michelle , Lee, Rachael M. , Reiter, Samantha , Sevola, Kara , Peng, Kah-Whye , Recker, Jordan , Packiriswamy, Nandakumar , Ramachandran, Sabarinathan , Balakrishnan, Baskar , Gnanadurai, Clement , Vandergaast, Rianna , Janecek, Jody L. , Waniger, Scott , Petro, Christopher D. , Kyratsous, Christos A.

in Adenoviridae / Adenoviruses / Allergy and Immunology / Animals / Antibodies / Antibodies, Neutralizing / Antibodies, Viral / Asymptomatic / Clinical trials / Complementation / COVID-19 / COVID-19 - prevention & control / Genomes / Glycoproteins / Herd immunity / Immune response / Immunity / Immunogenicity / Infections / intramuscular injection / Lipids / Liposomes / mRNA / Nanoparticles / Neutralizing antibodies / Oral vaccine / Primates / Proteins / Rhabdoviridae / Rhabdovirus / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Spike Glycoprotein, Coronavirus - genetics / Stomatitis / T cells / Tropism / Vaccines / Vesicular stomatitis / Viral diseases / Viral Vaccines / Virions / Viruses / VSV

2022

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Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine

2022

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Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine

2022

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Journal Article

Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine

Carey, Timothy,

Muñoz-Alía, Miguel Á.,

Baum, Alina,

Graham, Melanie L.,

Tesfay, Mulu,

Sakuma, Toshie,

Russell, Luke,

Krotova, Karina,

Russell, Stephen J.,

Lathrum, Chase,

Suksanpaisan, Lukkana,

Zhang, Lianwen,

Narjari, Riya,

Lech, Patrycja,

Ziegler, Christopher,

Haselton, Michelle,

Lee, Rachael M.,

Reiter, Samantha,

Sevola, Kara,

Peng, Kah-Whye,

Recker, Jordan,

Packiriswamy, Nandakumar,

Ramachandran, Sabarinathan,

Balakrishnan, Baskar,

Gnanadurai, Clement,

Vandergaast, Rianna,

Janecek, Jody L.,

Waniger, Scott,

Petro, Christopher D.,

Kyratsous, Christos A.

2022

Overview

An orally active vaccine capable of boosting SARS-CoV-2 immune responses in previously infected or vaccinated individuals would help efforts to achieve and sustain herd immunity. Unlike mRNA-loaded lipid nanoparticles and recombinant replication-defective adenoviruses, replicating vesicular stomatitis viruses with SARS-CoV-2 spike glycoproteins (VSV-SARS2) were poorly immunogenic after intramuscular administration in clinical trials. Here, by G protein trans-complementation, we generated VSV-SARS2(+G) virions with expanded target cell tropism. Compared to parental VSV-SARS2, G-supplemented viruses were orally active in virus-naive and vaccine-primed cynomolgus macaques, powerfully boosting SARS-CoV-2 neutralizing antibody titers. Clinical testing of this oral VSV-SARS2(+G) vaccine is planned.

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Publisher

Elsevier Ltd,Elsevier Limited,Published by Elsevier Ltd

Subject

Adenoviridae

/ Adenoviruses

/ Allergy and Immunology

/ Animals

/ Antibodies

/ Antibodies, Neutralizing

/ Antibodies, Viral