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Current applications of high-resolution mass spectrometry for the analysis of new psychoactive substances: a critical review
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Current applications of high-resolution mass spectrometry for the analysis of new psychoactive substances: a critical review
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Journal Article
Current applications of high-resolution mass spectrometry for the analysis of new psychoactive substances: a critical review
2017
Overview
The proliferation of new psychoactive substances (NPS) in recent years has resulted in the development of numerous analytical methods for the detection and identification of known and unknown NPS derivatives. High-resolution mass spectrometry (HRMS) has been identified as the method of choice for broad screening of NPS in a wide range of analytical contexts because of its ability to measure accurate masses using data-independent acquisition (DIA) techniques. Additionally, it has shown promise for non-targeted screening strategies that have been developed in order to detect and identify novel analogues without the need for certified reference materials (CRMs) or comprehensive mass spectral libraries. This paper reviews the applications of HRMS for the analysis of NPS in forensic drug chemistry and analytical toxicology. It provides an overview of the sample preparation procedures in addition to data acquisition, instrumental analysis, and data processing techniques. Furthermore, it gives an overview of the current state of non-targeted screening strategies with discussion on future directions and perspectives of this technique.
Graphical Abstract
Missing the bullseye - a graphical respresentation of non-targeted screening. Image courtesy of Christian Alonzo
Publisher
Springer Berlin Heidelberg,Springer,Springer Nature B.V
Subject
/ Animals
/ Characterization and Evaluation of Materials
/ Chemical Fractionation - methods
/ Chemistry and Materials Science
/ Designer Drugs - pharmacokinetics
/ Forensic Medicine - instrumentation
/ Humans
/ Ions
/ Mass Spectrometry - instrumentation
/ Methods
/ Monitoring/Environmental Analysis
/ Psychotropic Drugs - analysis
/ Review
/ Substance Abuse Detection - instrumentation
