Journal Article

Patients with type 2 diabetes present with multiple anomalies of the pancreatic arterial tree on abdominal computed tomography: comparison between patients with type 2 diabetes and a matched control group

Larger, Etienne, Dohan, Anthony, Barral, Matthias, Alexandre-Heymann, Laure

2020

Overview

Background Studies suggest that cardio-vascular risk factors could foster the development of type 2 diabetes (T2D). This could partly be mediated by pancreatic atherosclerosis resulting in pancreatic ischemia. We hypothesized that patients with T2D present with more severe atherosclerosis of pancreas-bound arteries than control patients without T2D. Methods We performed a retrospective study comparing the abdominal computed tomography of patients with T2D and of control subjects matched for gender and for age. We performed a multivariate logistic regression with adjustment for age, gender, BMI and the presence or absence of hypertension. Results Forty-eight patients with T2D and 48 control subjects were included. A calcification score of the splenic artery was defined (from 0: no calcification to 3: continuous linear calcifications). Seventeen percent of the patients with T2D presented with a high calcification score (i.e. 2 or 3), versus only 2% of the control subjects (p = 0.04). The mean number of pancreas-bound branches among the greater pancreatic artery, dorsal pancreatic artery and inferior pancreatic artery (from 0 to 3) was lower in patients with T2D than in control subjects (1.1 vs 1.7, p = 0.003). The mean number of visible intrapancreatic arterial subdivisions (from 0 to 2) was lower in patients with T2D than in control subjects (0.7 vs 1.3, p = 0.0017). All these differences hold true using multivariate logistic regression. None of these differences correlated with the duration of diabetes. The relationship between pancreas volume and BMI seen in control subjects was not confirmed in patients with T2D. Conversely, in patients with T2D but not in control subjects, the splenic artery diameter correlated with the pancreas volume. Conclusions Patients with T2D present with more calcifications of the splenic artery and with a less dense pancreatic arterial tree than control subjects.

• Publisher: BioMed Central,Springer Nature B.V,BMC
• Subject: Abdomen / Aged / Angiology / Arteries - abnormalities / Arteries - diagnostic imaging / Arteriosclerosis / Atherosclerosis / Atherosclerosis - complications / Atherosclerosis - diagnostic imaging / Branches / Calcification (ectopic) / Cardiology / Computed tomography / Computed Tomography Angiography / Contrast agents / Diabetes / Diabetes mellitus (non-insulin dependent) / Diabetes Mellitus, Type 2 - complications / Diabetes Mellitus, Type 2 - diagnosis / Diabetic retinopathy / Electronic health records / Female / Heart attacks / Humans / Hyperglycemia / Hypertension / Ischemia / Male / Medical imaging / Medical records / Medicine / Medicine & Public Health / Middle Aged / Original Investigation / Pancreas / Pancreas - blood supply / Pancreas density / Pancreas ischemia / Pancreas perfusion / Pancreas volume / Pancreatitis / Patients / Peripheral neuropathy / Plaque, Atherosclerotic / Predictive Value of Tests / Retrospective Studies / Risk Assessment / Risk Factors / Spleen / Splenic artery / Splenic Artery - diagnostic imaging / Type 2 diabetes / Vascular Calcification - complications / Vascular Calcification - diagnostic imaging / Vascular Malformations - complications / Vascular Malformations - diagnostic imaging / Veins & arteries