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Application of CRISPR genetic screens to investigate neurological diseases

by Lau, Heather H. C. , Schmitt-Ulms, Gerold , So, Raphaella W. L. , Al-Azzawi, Zaid A. M. , Joung, Julia , Watts, Jeremy J. , Lin, Lilian Tsai-Wei , Chung, Sai Wai , Gaudette, Erin , Wang, Xinzhu , Bishay, Jossana

in Animals / Biomedical and Life Sciences / Biomedicine / Clustered Regularly Interspaced Short Palindromic Repeats - genetics / CRISIPR KO / CRISPR-Cas Systems - genetics / CRISPR-Cas9 / CRISPRa / CRISPRi / Disease Models, Animal / Drug resistance / Functional genetics / Gene Editing / Genetic testing / Genetic Testing - methods / Genetics / Genomes / Genomics / Health screening / Humans / Investigations / Medical research / Molecular Medicine / Nervous system diseases / Neurodegenerative diseases / Neurodegenerative Diseases - genetics / Neurology / Neurosciences / Review / sgRNA / Technology / Technology application

2019

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2019

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2019

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Journal Article

Application of CRISPR genetic screens to investigate neurological diseases

Lau, Heather H. C.,

Schmitt-Ulms, Gerold,

So, Raphaella W. L.,

Al-Azzawi, Zaid A. M.,

Joung, Julia,

Watts, Jeremy J.,

Lin, Lilian Tsai-Wei,

Chung, Sai Wai,

Gaudette, Erin,

Wang, Xinzhu,

Bishay, Jossana

2019

Overview

The adoption of CRISPR-Cas9 technology for functional genetic screens has been a transformative advance. Due to its modular nature, this technology can be customized to address a myriad of questions. To date, pooled, genome-scale studies have uncovered genes responsible for survival, proliferation, drug resistance, viral susceptibility, and many other functions. The technology has even been applied to the functional interrogation of the non-coding genome. However, applications of this technology to neurological diseases remain scarce. This shortfall motivated the assembly of a review that will hopefully help researchers moving in this direction find their footing. The emphasis here will be on design considerations and concepts underlying this methodology. We will highlight groundbreaking studies in the CRISPR-Cas9 functional genetics field and discuss strengths and limitations of this technology for neurological disease applications. Finally, we will provide practical guidance on navigating the many choices that need to be made when implementing a CRISPR-Cas9 functional genetic screen for the study of neurological diseases.

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Publisher

BioMed Central,BioMed Central Ltd,BMC

Subject

Animals

/ Biomedical and Life Sciences

/ Biomedicine

/ Clustered Regularly Interspaced Short Palindromic Repeats - genetics

/ CRISIPR KO

/ CRISPR-Cas Systems - genetics

/ CRISPR-Cas9