Journal Article

The cisplatin-induced acute kidney injury is a novel risk factor for postoperative complications in patients with esophageal cancer: a retrospective cohort study

Tanaka, Tatsuya, Sagawa, Hiroyuki, Murashima, Miho, Ito, Sunao, Matsuo, Yoichi, Takahashi, Hiroki, Ogawa, Ryo, Ueno, Shuhei, Hayakawa, Shunsuke, Takiguchi, Shuji, Hamano, Takayuki, Mitsui, Akira, Kimura, Masahiro, Saito, Masaki, Okubo, Tomotaka

2023

Overview

Background Cisplatin-induced acute kidney injury (AKI) is common during preoperative chemotherapy for esophageal cancer. The purpose of this study was to investigate the association between AKI after preoperative chemotherapy and postoperative complications in patients with esophageal cancer. Methods In this retrospective cohort study, we included patients who had received preoperative chemotherapy with cisplatin and underwent surgical resection for esophageal cancer under general anesthesia from January 2017 to February 2022 at an education hospital. A predictor was stage 2 or higher cisplatin-induced AKI (c-AKI) defined by the KDIGO criteria within 10 days after chemotherapy. Outcomes were postoperative complications and length of hospital stays. Associations between c-AKI and outcomes including postoperative complications and length of hospital stays were examined with logistic regression models. Results Among 101 subjects, 22 developed c-AKI with full recovery of the estimated glomerular filtration (eGFR) before surgery. Demographics were not significantly different between patients with and without c-AKI. Patients with c-AKI had significantly longer hospital stays than those without c-AKI [mean (95% confidence interval (95%CI)) 27.6 days (23.3–31.9) and 43.8 days (26.5–61.2), respectively, mean difference (95%CI) 16.2 days (4.4–28.1)]. Those with c-AKI had higher C-reactive protein (CRP) levels and prolonged weight gain after surgery and before the events of interest despite having comparable eGFR trajectories after surgery. c-AKI was significantly associated with anastomotic leakage and postoperative pneumonia [odds ratios (95%CI) 4.14 (1.30–13.18) and 3.87 (1.35–11.0), respectively]. Propensity score adjustment and inverse probability weighing yielded similar results. Mediation analysis showed that a higher incidence of anastomotic leakage in patients with c-AKI was primarily mediated by CRP levels (mediation percentage 48%). Conclusion c-AKI after preoperative chemotherapy in esophageal cancer patients was significantly associated with the development of postoperative complications and led to a resultant longer hospital stay. Increased vascular permeability and tissue edema due to prolonged inflammation might explain the mechanisms for the higher incidence of postoperative complications.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Acute kidney injury / Acute Kidney Injury - chemically induced / Acute Kidney Injury - epidemiology / Anastomotic Leak / Anastomotic leakage / Anesthesia / Antimitotic agents / Antineoplastic agents / Bacterial pneumonia / C-reactive protein / Cancer / Cancer patients / Chemotherapy / Cisplatin / Cisplatin - adverse effects / Cohort analysis / Complications / Confidence intervals / Creatinine / Disease / Edema / Epidermal growth factor receptors / Esophageal cancer / Esophageal Neoplasms - drug therapy / Esophageal Neoplasms - surgery / Esophagus / Hemoglobin / Hospitals / Humans / Incidence / Internal Medicine / Kidneys / Length of stay / Mediation / Medicine / Medicine & Public Health / Oncology, Experimental / Patients / Permeability / Pneumonia / Postoperative / Postoperative complications / Postoperative Complications - epidemiology / Postoperative Complications - etiology / Postoperative period / Preoperative chemotherapy / Proteins / Regression analysis / Regression models / Retrospective Studies / Review boards / Risk Factors / Statistical analysis / Surgery / Urine / Variables