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Pituitary adenoma consistency affects postoperative hormone function: a retrospective study
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Pituitary adenoma consistency affects postoperative hormone function: a retrospective study
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Pituitary adenoma consistency affects postoperative hormone function: a retrospective study
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Journal Article
Pituitary adenoma consistency affects postoperative hormone function: a retrospective study
2023
Overview
Background
Tumor consistency recently emerged as a key factor in surgical planning for pituitary adenomas, but its impact on postoperative endocrine function is still unclear. Our study aimed to evaluate the impact of tumor consistency on the development of postoperative pituitary deficiencies.
Methods
Single-center, retrospective analysis of consecutive pituitary surgeries performed between January 2017 and January 2021 at Policlinico Umberto I in Rome. All patients underwent radiological and biochemical evaluations at baseline, and hormone assessments 3 and 6 months after pituitary surgery. Postoperative MRI studies were used to determine resection rates following surgery. Data on tumor consistency, macroscopic appearance, neurosurgical approach, and intraoperative complications were collected.
Results
Fifty patients [24 women, mean age 57 ± 13 years, median tumor volume 4800 mm
3
[95% CI 620–8828], were included. Greater tumor volume (χ
2
= 14.621,
p
= 0.006) and male sex (χ
2
= 12.178,
p
< 0.001) were associated with worse preoperative endocrine function. All patients underwent transsphenoidal adenomectomy. Fibrous consistency was observed in 10% of patients and was associated with a Ki-67 greater than 3% (χ
2
= 8.154,
p
= 0.04), greater risk of developing postoperative hormone deficiencies (χ
2
= 4.485,
p
= 0.05, OR = 8.571; 95% CI: 0.876–83.908), and lower resection rates (χ2 = 8.148,
p
= 0.004; OR 1.385, 95% CI; 1.040–1.844). Similarly, worse resection rates were observed in tumors with suprasellar extension (χ2 = 5.048,
p
= 0.02; OR = 6.000, 95% CI; 1.129–31.880) and CSI (χ2 = 4.000,
p
= 0.04; OR = 3.857, 95% CI; 0.997–14.916).
Conclusions
Tumor consistency might provide useful information about postoperative pituitary function, likely due to its impact on surgical procedures. Further prospective studies with larger cohorts are needed to confirm our preliminary findings.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adult
/ Aged
/ Analysis
/ Diabetes
/ Female
/ Hormones
/ Humans
/ Male
/ Medicine
/ Patients
/ Pituitary Neoplasms - complications
/ Pituitary Neoplasms - diagnostic imaging
/ Pituitary Neoplasms - surgery
/ Postoperative Complications - epidemiology
/ Postoperative Complications - etiology
/ Postoperative pituitary function
/ rology
/ Surgery
/ Tumors
