Journal Article

Impaired 24-h activity patterns are associated with an increased risk of Alzheimer’s disease, Parkinson’s disease, and cognitive decline

Winer, Joseph R., Weed, Lara, He, Zihuai, Mormino, Elizabeth C., Zeitzer, Jamie M., Lok, Renske, Poston, Kathleen L.

2024

Overview

Background Sleep-wake regulating circuits are affected during prodromal stages in the pathological progression of both Alzheimer’s disease (AD) and Parkinson’s disease (PD), and this disturbance can be measured passively using wearable devices. Our objective was to determine whether accelerometer-based measures of 24-h activity are associated with subsequent development of AD, PD, and cognitive decline. Methods This study obtained UK Biobank data from 82,829 individuals with wrist-worn accelerometer data aged 40 to 79 years with a mean (± SD) follow-up of 6.8 (± 0.9) years. Outcomes were accelerometer-derived measures of 24-h activity (derived by cosinor, nonparametric, and functional principal component methods), incident AD and PD diagnosis (obtained through hospitalization or primary care records), and prospective longitudinal cognitive testing. Results One hundred eighty-seven individuals progressed to AD and 265 to PD. Interdaily stability (a measure of regularity, hazard ratio [HR] per SD increase 1.25, 95% confidence interval [CI] 1.05–1.48), diurnal amplitude (HR 0.79, CI 0.65–0.96), mesor (mean activity; HR 0.77, CI 0.59–0.998), and activity during most active 10 h (HR 0.75, CI 0.61–0.94), were associated with risk of AD. Diurnal amplitude (HR 0.28, CI 0.23–0.34), mesor (HR 0.13, CI 0.10–0.16), activity during least active 5 h (HR 0.24, CI 0.08–0.69), and activity during most active 10 h (HR 0.20, CI 0.16–0.25) were associated with risk of PD. Several measures were additionally predictive of longitudinal cognitive test performance. Conclusions In this community-based longitudinal study, accelerometer-derived metrics were associated with elevated risk of AD, PD, and accelerated cognitive decline. These findings suggest 24-h rhythm integrity, as measured by affordable, non-invasive wearable devices, may serve as a scalable early marker of neurodegenerative disease.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Accelerometers / Advertising executives / Alzheimer Disease - complications / Alzheimer Disease - epidemiology / Alzheimer's disease / Biobanks / Biomedical and Life Sciences / Biomedicine / Body mass index / Cognitive aging / Cognitive Dysfunction - psychology / Data collection / Development and progression / Disease / Exercise / Geriatric Psychiatry / Geriatrics/Gerontology / Health aspects / Humans / Intelligence tests / Longitudinal Studies / Medical records / Neurodegenerative Diseases / Neurology / Neurosciences / Older people / Parkinson Disease - epidemiology / Parkinson's disease / Prospective Studies / Rest-activity rhythms / Risk factors / Sleep / Sleep-wake cycle / Statistics