Journal Article

Association between the systemic immune inflammation index and periodontitis: a cross-sectional study

Lai, Wenjing, Zhang, Gang, Li, Guobing, Hu, Changpeng, Zheng, Weiwei, Guo, Junfeng, He, Haitao, Zhang, Rong, Xu, Rufu, Liu, Rongxing

2024

Overview

Background Periodontitis is a chronic oral inflammatory disease that seriously affects people's quality of life. The purpose of our study was to investigate the correlation between the systemic immune inflammation index (SII) and periodontitis by utilizing a large national survey. This will establish a reference for the early identification and management of periodontitis. Methods This study comprised the adult US population who participated in a national periodontitis surveillance project during the six years from 2009 to 2014. Through the utilization of univariate and multivariate weighted logistic regression, we investigated the correlation between the systemic immune inflammation index and periodontitis. Additionally, we employed sensitivity analyses to evaluate the robustness of our findings. Results The study involved 10,366 participants with an average age of 51.00 years, of whom 49.45% were male (N = 5126) and 50.55% were female (N = 5240). The prevalence of periodontitis is estimated to be about 38.43% in the US adults aged 30 or older population. Our logistic regression models indicated a positive association between a SII higher than 978 × 10 9 /L and periodontitis. The elder group (aged 50 or older) with SII higher than 978 × 10 9 /L demonstrated a significant correlation with periodontitis in the fully adjusted model (Odds Ratio [OR] = 1.409, 95% Confidence Interval [CI] 1.037, 1.915, P  = 0.022). However, there is no statistical difference among adults aged 30 to 50. The robustness of our findings was confirmed through sensitivity analyses. Conclusions Our study highlights that SII is associated with periodontitis in a nationally representative sample of US adults. And the SII is significantly associated with a high risk of periodontitis in individuals aged 50 or older.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Analysis / Biomedical and Life Sciences / Biomedicine / Blood platelets / Body mass index / Cancer / Cardiovascular disease / Care and treatment / Cross-Sectional Studies / Cross-sectional study / Diabetes / Female / Gum disease / Heart attacks / Humans / Hypertension / Immune response / Inflammation / Inflammatory diseases / Logistic Models / Lymphocytes / Male / Management / Medicine/Public Health / Middle Aged / National Health and Nutrition Examination Survey (NHANES) / Neutrophils / Periodontitis / Population / Prognosis / Public health / Quality of Life / Regression analysis / Risk factors / Secondary schools / Sensitivity analysis / Stroke / Surveillance / Teeth / Translational Craniofacial and Dental Medicine