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Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants
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Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants
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Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants
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Journal Article
Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants
2006
Overview
De novo
lymphangiogenesis influences the course of different human diseases as diverse as chronic renal transplant rejection
1
and tumor metastasis
2
,
3
. The cellular mechanisms of lymphangiogenesis in human diseases are currently unknown, and could involve division of local preexisting endothelial cells or incorporation of circulating progenitors. We analyzed renal tissues of individuals with gender-mismatched transplants who had transplant rejection and high rates of overall lymphatic endothelial proliferation as well as massive chronic inflammation. Donor-derived cells were detected by
in situ
hybridization of the Y chromosome. We compared these tissues with biopsies of essentially normal skin and intestine, and two rare carcinomas with low rates of lymphatic endothelial proliferation that were derived from individuals with gender-mismatched bone marrow transplants. Here, we provide evidence for the participation of recipient-derived lymphatic progenitor cells in renal transplants. In contrast, lymphatic vessels of normal tissues and those around post-transplant carcinomas did not incorporate donor-derived progenitors. This indicates a stepwise mechanism of inflammation-associated
de novo
lymphangiogenesis, implying that potential lymphatic progenitor cells derive from the circulation, transmigrate through the connective tissue stroma, presumably in the form of macrophages, and finally incorporate into the growing lymphatic vessel.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ Bone Marrow Transplantation - adverse effects
/ Bone Marrow Transplantation - pathology
/ Cells
/ Endothelial Cells - pathology
/ Female
/ Humans
/ In Situ Hybridization, Fluorescence
/ Kidney Transplantation - adverse effects
/ Kidney Transplantation - pathology
/ Kidneys
/ letter
/ Lymphangiogenesis - genetics
/ Lymphangiogenesis - physiology
/ Male
/ Tissues
/ Tumors
