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Journal Article
Nitrosative Stress, Uric Acid, and Peripheral Nerve Function in Early Type 1 Diabetes
2002
Overview
Nitrosative Stress, Uric Acid, and Peripheral Nerve Function in Early Type 1 Diabetes
Robert D. Hoeldtke 1 ,
Kimberly D. Bryner 1 ,
Daniel R. McNeill 1 ,
Gerald R. Hobbs 2 ,
Jack E. Riggs 3 ,
Sarah S. Warehime 1 ,
Ian Christie 4 ,
Gary Ganser 4 and
Knox Van Dyke 5
1 Department of Medicine, West Virginia University (WVU), Morgantown, West Virginia
2 Department of Community Medicine and Statistics, WVU, Morgantown, West Virginia
3 Department of Neurology, WVU, Morgantown, West Virginia
4 Department of Mathematics, WVU, Morgantown, West Virginia
5 Department of Biochemistry and Molecular Pharmacology, WVU, Morgantown, West Virginia
Abstract
The present study was performed to determine whether nitric oxide overproduction is associated with deterioration in peripheral
nerve function in type 1 diabetes. We measured peripheral nerve function and biochemical indicators of nitrosative stress
annually for 3 years in 37 patients with type 1 diabetes. Plasma nitrite and nitrate (collectively NO x ) were 34.0 ± 4.9 μmol/l in the control subjects and 52.4 ± 5.1, 50.0 ± 5.1, and 49.0 ± 5.2 in the diabetic patients at the
first, second, and third evaluations, respectively ( P < 0.01). Nitrotyrosine (NTY) was 13.3 ± 2.0 μmol/l in the control subjects and 26.8 ± 4.4, 26.1 ± 4.3, and 32.7 ± 4.3 in
the diabetic patients ( P < 0.01). Uric acid was suppressed by 20% in the diabetic patients ( P < 0.001). Composite motor nerve conduction velocity for the median, ulnar, and peroneal nerves was decreased in patients
with high versus low NTY (mean Z score −0.522 ± 0.25 versus 0.273 ± 0.22; P < 0.025). Patients with high NO x had decreased sweating, and those with suppressed uric acid had decreased autonomic function. In conclusion, nitrosative
stress in early diabetes is associated with suppressed uric acid and deterioration in peripheral nerve function.
Footnotes
Address correspondence and reprint requests to Robert D. Hoeldtke, West Virginia University School of Medicine, Department
of Medicine, One Medical Center Drive, PO Box 9159, Morgantown, WV 26506-9159.
Received for publication 3 April 2002 and accepted in revised form 28 May 2002.
8-iso-PGF2α, 8-isoprostaglandin F2α; ELISA, enzyme-linked immunosorbent assay; eNOS, endothelial nitric oxide synthase; HPLC,
high-performance liquid chromatography; iNOS, inducible nitric oxide synthase; NTY, nitrotyrosine; TY, tyrosine; VMA, vanillylmandelic
acid.
DIABETES
Publisher
American Diabetes Association
Subject
/ Adult
/ Associated diseases and complications
/ Autonomic Nervous System - physiopathology
/ Biological and medical sciences
/ Child
/ Diabetes
/ Diabetes Mellitus, Type 1 - metabolism
/ Diabetes Mellitus, Type 1 - physiopathology
/ Diabetes. Impaired glucose tolerance
/ Diet
/ Dinoprost - analogs & derivatives
/ Endocrine pancreas. Apud cells (diseases)
/ Female
/ Glucose
/ Heart Conduction System - physiopathology
/ Humans
/ Male
/ Peripheral Nerves - physiopathology
/ Peroxynitrous Acid - metabolism
/ Sweating
