Journal Article

The impact of incident stroke on cognitive trajectories in later life

Donnan, Geoffrey A., Sood, Ajay, Hopper, Ingrid, Tonkin, Andrew M., Woods, Robyn L., Vishwanath, Swarna, Reid, Christopher M., Orchard, Suzanne G., Williamson, Jeff D., Eaton, Charles B., Shah, Raj C., Nelson, Mark R., Steves, Claire J., Wolfe, Rory, Murray, Anne M., Ryan, Joanne, Fitzgerald, Sharyn, Cloud, Geoffrey C., Chong, Trevor T-J

2024

Overview

Background Cognitive impairment is common after stroke, and a large proportion of stroke patients will develop dementia. However, there have been few large prospective studies which have assessed cognition both prior to and after stroke. This study aims to determine the extent to which incident stroke impacts different domains of cognitive function in a longitudinal cohort of older community-dwelling individuals. Methods 19,114 older individuals without cardiovascular disease or major cognitive impairment were recruited and followed over a maximum 11 years. Stroke included ischaemic and haemorrhagic stroke and was adjudicated by experts. Cognitive function was assessed regularly using Modified Mini-Mental State Examination (3MS), Hopkins Verbal Learning Test–Revised (HVLT-R), Symbol Digit Modalities Test (SDMT), and Controlled Oral Word Association Test (COWAT). Linear mixed models were used to investigate the change in cognition at the time of stroke and decline in cognitive trajectories following incident stroke. Results During a median follow-up period of 8.4 [IQR: 7.2, 9.6] years, 815 (4.3%) participants experienced a stroke. Over this time, there was a general decline observed in 3MS, HVLT-R delayed recall, and SDMT scores across participants. However, for individuals who experienced a stroke, there was a significantly greater decline across all cognitive domains immediately after the event immediately after the event (3MS: -1.03 [95%CI: -1.45, -0.60]; HVLT-R: -0.47 [-0.70, -0.24]; SDMT: -2.82 [-3.57, -2.08]; COWAT: -0.67 [-1.04, -0.29]) and a steeper long-term decline for three of these domains (3MS -0.62 [-0.88, -0.35]; COWAT: -0.30 [-0.46, -0.14]); HVLT-R: -0.12 [95%CI, -0.70, -0.24]). However individuals with stroke experienced no longer-term decline in SDMT compared to the rest of the participants. Conclusions These findings highlight the need for comprehensive neuropsychology assessments for ongoing monitoring of cognition following incident stroke; and potential early intervention.

• Publisher: BioMed Central,BioMed Central Ltd,BMC
• Subject: Aged / Aged, 80 and over / Analysis / Biomedical and Life Sciences / Biomedicine / Cardiovascular diseases / Cognition / Cognition - physiology / Cognition disorders in old age / Cognitive domains / Cognitive Dysfunction - diagnosis / Cognitive Dysfunction - epidemiology / Cognitive Dysfunction - etiology / Cognitive function / Complications and side effects / Dementia / Demographic aspects / Female / Geriatric Psychiatry / Geriatrics/Gerontology / Humans / Incidence / Linear mixed model / Longitudinal Studies / Male / Neurology / Neuropsychological Tests / Neurosciences / Prospective Studies / Risk factors / Stroke / Stroke (Disease) / Stroke - complications / Stroke - epidemiology / Stroke - psychology / Trajectories