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FXYD6： a novel therapeutic target toward hepatocellular carcinoma
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FXYD6： a novel therapeutic target toward hepatocellular carcinoma
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Journal Article
FXYD6： a novel therapeutic target toward hepatocellular carcinoma
2014
Overview
FXYD6, FXYD domain containing ion transport regulator 6, has been reported to affect the activity of Na＋/K＋-ATP- ase and be associated with mental diseases. Here, we demonstrate that FXYD6 is up-regulated in hepatocellular carcinoma （HCC） and enhances the migration and prolif- eration of HCC cells. Up-regulation of FXYD6 not only positively correlates with the increase of Na＋IK＋-ATPase but also coordinates with the activation of its downstream Src-ERK signaling pathway. More importantly, blocking FXYD6 by its functional antibody significantly inhibits the growth potential of the xenografted HCC tumors in mice, indicating that FXYD6 represents a potential therapeutic target toward HCC. Altogether, our results establish a critical role of FXYD6 in HCC progression and suggest that the therapy targeting FXYD6 can benefit the clinical treatment toward HCC patients.
Publisher
Higher Education Press,Springer Nature B.V
Subject
/ Antibodies, Monoclonal - pharmacology
/ Antineoplastic Agents - pharmacology
/ ATP酶
/ Biomedical and Life Sciences
/ Carcinoma, Hepatocellular - drug therapy
/ Carcinoma, Hepatocellular - metabolism
/ Female
/ FXYD6
/ hepatocellular carcinoma (HCC)
/ Humans
/ Ion Channels - antagonists & inhibitors
/ Liver Neoplasms - drug therapy
/ Liver Neoplasms - metabolism
/ Sodium-Potassium-Exchanging ATPase - metabolism
/ Tumors
/ Xenograft Model Antitumor Assays
/ 临床治疗
/ 信号传导途径
/ 异种移植
/ 离子传导
/ 精神疾病
/ 肝癌细胞
/ 肝细胞癌
