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The cellular and signaling networks linking the immune system and metabolism in disease
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Journal Article
The cellular and signaling networks linking the immune system and metabolism in disease
2012
Overview
It is now recognized that obesity is driving the type 2 diabetes epidemic in Western countries. Obesity-associated chronic tissue inflammation is a key contributing factor to type 2 diabetes and cardiovascular disease, and a number of studies have clearly demonstrated that the immune system and metabolism are highly integrated. Recent advances in deciphering the various cellular and signaling networks that participate in linking the immune and metabolic systems together have contributed to understanding of the pathogenesis of metabolic diseases and may also inform new therapeutic strategies based on immunomodulation. Here we discuss how these various networks underlie the etiology of the inflammatory component of insulin resistance, with a particular focus on the central roles of macrophages in adipose tissue and liver.
This review highlights the importance of immunometabolism to obesity and metabolic diseases such as diabetes. The authors describe recent advances in dissecting the cellular and signaling networks that link the immune and metabolic systems together, and how these insights could be translated to develop new therapeutic strategies to combat metabolic disease.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ Cardiovascular Diseases - complications
/ Cardiovascular Diseases - immunology
/ Cardiovascular Diseases - metabolism
/ Cellular signal transduction
/ Complications and side effects
/ Diabetes
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - immunology
/ Diabetes Mellitus, Type 2 - metabolism
/ Etiology
/ Humans
/ Inflammation - complications
/ Insulin Resistance - immunology
/ Metabolic Diseases - immunology
/ Metabolic Networks and Pathways
/ Obesity
