Journal Article

Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population

Sunagawa, Hiroshi, Kanda, Hideyuki, Kobayashi- Miura, Mikiko, Yamamoto, Mai, Kikuchi, Shinya, Mahbub, MH, Nakamura, Mina, Yamamoto, Hiroshi, Takasu, Mariko, Fujita, Yasuyuki, Tanabe, Tsuyoshi, Takahashi, Hidekazu, Hase, Ryosuke, Ishimaru, Yasutaka, Yamaguchi, Natsu, Amano, Hiroki, Ikeda, Atsuko, Kageyama, Naoko

2017

Overview

Background Recently, the association of plasma free amino acid (PFAA) profile and lifestyle-related diseases has been reported. However, few studies have been reported in large Asian populations, about the usefulness of PFAAs for evaluating disease risks. We examined the ability of PFAA profiles to evaluate lifestyle-related diseases in so far the largest Asian population. Methods We examined plasma concentrations of 19 amino acids in 8589 Japanese subjects, and determined the association with variables associated with obesity, blood glucose, lipid, and blood pressure. We also evaluated the PFAA indexes that reflect visceral fat obesity and insulin resistance. The contribution of single PFAA level and relevant PFAA indexes was also examined in the risk assessment of lifestyle-related diseases. Results Of the 19 amino acids, branched-chain amino acids and aromatic amino acids showed association with obesity and lipid variables. The PFAA index related to visceral fat obesity showed relatively higher correlation with variables than that of any PFAA. In the evaluation of lifestyle-related disease risks, the odds ratios of the PFAA index related to visceral fat obesity or insulin resistance with the diseases were higher than most of those of individual amino acid levels even after adjusting for potential confounding factors. The association pattern of the indexes and PFAA with each lifestyle-related disease was distinct. Conclusions We confirmed the usefulness of PFAA profiles and indexes as markers for evaluating the risks of lifestyle-related diseases, including diabetes mellitus, metabolic syndrome, dyslipidemia, and hypertension in a large Asian population.

• Publisher: BioMed Central,Komiyama Printing Co., Ltd,Komiyama Printing Co. Ltd
• Subject: Adult / Age / Aged / Amino acids / Amino Acids - blood / Antihypertensives / Asian Continental Ancestry Group / Biomarkers / Blood Glucose / Blood Pressure / Body Mass Index / Chain branching / Cholesterol / Diabetes / Diabetes mellitus / Diabetes Mellitus, Type 2 - blood / Diabetes Mellitus, Type 2 - epidemiology / Disease / Dyslipidemia / Dyslipidemias - blood / Dyslipidemias - epidemiology / Environmental health / Evaluation / Female / Gender / Health Promotion and Disease Prevention / Health risks / Humans / Hypertension / Hypertension - blood / Hypertension - epidemiology / Insulin / Insulin resistance / Japan - epidemiology / Lifestyle-related diseases / Lifestyles / Lipids / Lipids - blood / Male / Medicine / Medicine & Public Health / Metabolic disorders / Metabolic syndrome / Metabolic Syndrome - blood / Metabolic Syndrome - epidemiology / Middle Aged / Obesity / Obesity - blood / Obesity - epidemiology / Plasma / Public Health / Regression analysis / Research Article / Risk assessment / Risk Factors / Variables