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Gut microbiota in patients with prostate cancer: a systematic review and meta-analysis
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Gut microbiota in patients with prostate cancer: a systematic review and meta-analysis
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Journal Article
Gut microbiota in patients with prostate cancer: a systematic review and meta-analysis
2024
Overview
Background
Increasing evidence indicates that gut microbiota are closely related to prostate cancer. This study aims to assess the gut microbiota composition in patients with prostate cancer compared to healthy participants, thereby advancing understanding of gut microbiota's role in prostate cancer.
Methods
A systematic search was conducted across PubMed, Web of Science, and Embase databases, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The methodological quality of included studies was evaluated using the Newcastle–Ottawa Scale (NOS), and pertinent data were analyzed. The kappa score assessed interrater agreement.
Results
This study encompassed seven research papers, involving 250 prostate cancer patients and 192 controls. The kappa was 0.93. Meta-analysis results showed that alpha-diversity of gut microbiota in prostate cancer patients was significantly lower than in the control group. In terms of gut microbiota abundance, the ratio of
Proteobacteria
,
Bacteroidia
,
Clostridia
,
Bacteroidales
,
Clostridiales
,
Prevotellaceae
,
Lachnospiraceae
,
Prevotella
,
Escherichia
-
Shigella
,
Faecalibacterium
, and
Bacteroides
was higher in prostate cancer patients. Conversely, the abundance ratio of
Actinobacteria
,
Bacteroidetes
,
Firmicutes
,
Selenomonadales
,
Veillonella
, and
Megasphaera
was higher in the control group.
Conclusion
Our study reveals differences in alpha-diversity and abundance of gut microbiota between patients with prostate cancer and controls, indicating gut microbiota dysbiosis in those with prostate cancer. However, given the limited quality and quantity of selected studies, further research is necessary to validate these findings.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Analysis
/ Bacteria
/ Bacteria - isolation & purification
/ Biomedical and Life Sciences
/ Citation management software
/ Health Promotion and Disease Prevention
/ Humans
/ Male
/ Microbiota (Symbiotic organisms)
/ Oncology
/ Prostatic Neoplasms - microbiology
/ Systematic review and meta-analysis
/ Taxonomy
