Journal Article

GA/HbA1c ratio is a simple and practical indicator to evaluate the risk of metabolic dysfunction-associated fatty liver disease in type 2 diabetes: an observational study

Ma, Yi-Lin, Lu, Jun-Xi, Wang, Jun-Wei, Wang, Yu-Jie, Jin, Chun-Hua, Ke, Jiang-Feng, Li, Mei-Fang, Li, Lian-Xi

2022

Overview

Background It is still debatable whether glycated albumin/glycated hemoglobin A1C (GA/HbA1C) ratio is associated with metabolic dysfunction-associated fatty liver disease (MAFLD), and few studies have been conducted in type 2 diabetes mellitus (T2DM). Therefore, we aimed to investigate the association between GA/HbA1C ratio and MAFLD and to evaluate whether GA/HbA1C ratio can be used an indicator of MAFLD in Chinese patients with T2DM. Methods This cross-sectional study consisted of 7117 T2DM patients including 3296 men and 3821 women from real-world settings. Abdominal ultrasonography was performed to diagnose MAFLD. In addition to comparing the clinical characteristics among the GA/HbA1C ratio quartile groups, we also investigated the associations of GA/HbA1C ratio and quartiles with MAFLD in T2DM subjects. Results There was a significantly decreased trend in the MAFLD prevalence across the GA/HbA1C ratio quartiles (56.3%, 47.4%, 37.8%, and 35.6% for the first, second, third, and fourth quartile, respectively, P < 0.001 for trend) after adjusting for gender, age, and diabetes duration. Fully adjusted Binary logistic regression indicated that both GA/HbA1C ratio (OR: 0.575, 95% CI: 0.471 to 0.702, P < 0.001) and quartiles (P < 0.001 for trend) were inversely associated with the presence of MAFLD among T2DM patients. Additionally, HOMA2-IR values were clearly increased in the T2DM subjects with MAFLD compared with those without MAFLD (P < 0.001), and markedly increased from the highest to the lowest GA/HbA1C ratio quartile (P < 0.001 for trend). Conclusions GA/HbA1C ratio is closely and negatively associated with MAFLD in T2DM subjects, which may attribute to that GA/HbA1C ratio reflects the degree of insulin resistance. GA/HbA1C ratio may act as a simple and practical indicator to evaluate the risk of MAFLD in T2DM.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Abdomen / Age / Alcohol / Blood pressure / Body mass index / Cholesterol / Diabetes / Diabetes mellitus (non-insulin dependent) / Diagnosis / Diagnostic imaging / Endocrinology / Fatty liver / GA/HbA1C ratio / Gender / Glucose / Glycated albumin/glycated hemoglobin A1C / Glycosylated hemoglobin / Hemoglobin / Hypertension / Insulin / Insulin resistance / Laboratories / Liver diseases / Medical research / Medicine / Medicine & Public Health / Medicine, Experimental / Metabolic Diseases / Metabolic disorders / Metabolic dysfunction-associated fatty liver disease / Non-alcoholic fatty liver disease / Obesity / Observational studies / Patients / Peptides / Regression analysis / Type 2 diabetes / Type 2 diabetes mellitus