Asset Details
Do you wish to reserve the book?
Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1
Do you wish to request the book?
Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1
2007
Overview
The cornified layer is a compacted lattice of lipid-embedded corneocytes that provides an organism's barrier to the external environment. Cornification is the final differentiative step for epidermal keratinocytes and involves dramatic cell condensation before death. Using conditional gene deletion in mice, we identified the transcriptional repressor Blimp-1 (B lymphocyte-induced maturation protein-1) as an important regulator of keratinocyte transition from the granular to the cornified layer. More than 250 genes are misregulated in conditional knockout epidermis, including those encoding transcription factors, signal transduction components, proteinases, and enzymes involved in lipid metabolism. Steady-state mRNA and ChIP analyses of a subset of these genes provide evidence that nfat5, fos, prdm1, and dusp16 are novel direct targets of Blimp-1. Identifying nfat5 as a target of Blimp-1 repression indicates that cornification involves suppression of normal osmotic regulation in granular cells. Consistently, conditional knockout mice have delayed barrier formation as embryos, enlarged granular layer cells and corneocytes, and a morphologically abnormal cornified layer. These studies provide insight into cornification, identifying transcriptional regulatory circuitry and indicating the importance of blocking osmotic homeostasis.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Cells
/ death
/ Dual-Specificity Phosphatases - genetics
/ Dual-Specificity Phosphatases - metabolism
/ Embryonic Structures - metabolism
/ Genes
/ Humans
/ Lipids
/ Mice
/ Mitogen-Activated Protein Kinase Phosphatases - genetics
/ Mitogen-Activated Protein Kinase Phosphatases - metabolism
/ NFATC Transcription Factors - genetics
/ NFATC Transcription Factors - metabolism
/ Oligonucleotide Array Sequence Analysis
/ Positive Regulatory Domain I-Binding Factor 1
/ Proteins
/ Proto-Oncogene Proteins c-fos - genetics
/ Proto-Oncogene Proteins c-fos - metabolism
/ Repressor Proteins - genetics
/ Repressor Proteins - metabolism
/ Skin
