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Circulating microRNAs as stable blood-based markers for cancer detection

by Peterson, Amelia , Allen, April , Nelson, Peter S , Pogosova-Agadjanyan, Era L , Knudsen, Beatrice S , Gentleman, Robert , Stirewalt, Derek L , Parkin, Rachael K , Mitchell, Patrick S , Tewari, Muneesh , O'Briant, Kathy C , Kroh, Evan M , Drescher, Charles W , Vessella, Robert L , Lin, Daniel W , Urban, Nicole , Noteboom, Jennifer , Fritz, Brian R , Wyman, Stacia K , Martin, Daniel B

in Animals / Biological markers / Biological Sciences / Biomarkers, Tumor - genetics / Blood / Blood plasma / blood serum / Cancer / Cell lines / Cloning, Molecular / Gene Expression Profiling / Gene Expression Regulation, Neoplastic / Heterologous transplantation / Humans / Male / Mice / MicroRNA / MicroRNAs - blood / MicroRNAs - genetics / morbidity / Mortality / Neoplasm Transplantation / Neoplasms - metabolism / patients / Plasma / Prostate / Prostate cancer / prostatic neoplasms / Prostatic Neoplasms - blood / Prostatic Neoplasms - genetics / ribonucleases / Ribonucleases - metabolism / Ribonucleic acid / RNA / RNA, Neoplasm - blood / RNA, Neoplasm - metabolism / Sensitivity and Specificity / Tissues / Tumors

2008

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Circulating microRNAs as stable blood-based markers for cancer detection

2008

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2008

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Journal Article

Circulating microRNAs as stable blood-based markers for cancer detection

Peterson, Amelia,

Allen, April,

Nelson, Peter S,

Pogosova-Agadjanyan, Era L,

Knudsen, Beatrice S,

Gentleman, Robert,

Stirewalt, Derek L,

Parkin, Rachael K,

Mitchell, Patrick S,

Tewari, Muneesh,

O'Briant, Kathy C,

Kroh, Evan M,

Drescher, Charles W,

Vessella, Robert L,

Lin, Daniel W,

Urban, Nicole,

Noteboom, Jennifer,

Fritz, Brian R,

Wyman, Stacia K,

Martin, Daniel B

2008

Overview

Improved approaches for the detection of common epithelial malignancies are urgently needed to reduce the worldwide morbidity and mortality caused by cancer. MicroRNAs (miRNAs) are small ([almost equal to]22 nt) regulatory RNAs that are frequently dysregulated in cancer and have shown promise as tissue-based markers for cancer classification and prognostication. We show here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity. miRNAs originating from human prostate cancer xenografts enter the circulation, are readily measured in plasma, and can robustly distinguish xenografted mice from controls. This concept extends to cancer in humans, where serum levels of miR-141 (a miRNA expressed in prostate cancer) can distinguish patients with prostate cancer from healthy controls. Our results establish the measurement of tumor-derived miRNAs in serum or plasma as an important approach for the blood-based detection of human cancer.

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Publisher

National Academy of Sciences,National Acad Sciences

Subject

Animals

/ Biological markers

/ Biological Sciences

/ Biomarkers, Tumor - genetics

/ Blood

/ Blood plasma

/ blood serum