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Expressions and prognostic values of the E2F transcription factors in human breast carcinoma
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Expressions and prognostic values of the E2F transcription factors in human breast carcinoma
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Expressions and prognostic values of the E2F transcription factors in human breast carcinoma
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Journal Article
Expressions and prognostic values of the E2F transcription factors in human breast carcinoma
2018
Overview
transcription factors (
) are a family of transcription factors involved in cell proliferation, differentiation, and apoptosis. Their important roles in the development and metastasis of breast carcinoma (BC) have been discovered by previous in vitro and in vivo studies. Yet, expressions and distinct prognostic values of these eight
in human BC remain unclear in many respects. In this study, we aimed to reveal their roles in BC through analyzing the transcription and survival data of the
in BC patients from four online databases including ONCOMINE, Breast Cancer Gene-Expression Miner v4.1, cBioPortal for Cancer Genomics, and Kaplan-Meier Plotter. We found the overexpression of
in BC tissues compared with normal breast tissues, except for
. Higher expression levels of
, except for
and
, were associated with higher levels of Scarff-Bloom-Richardson grade of BC. Alterations of
were found to be significantly correlated with poorer overall survival of BC patients. Through plotting the survival curve in the Kaplan-Meier Plotter, it was found that higher mRNA levels of
,
,
, and
were associated with poorer relapse-free survival in all BC patients, indicating that they are potential targets for individualized treatments of BC patients. Conversely, higher mRNA expression level of
predicted better RFS in BC patients, suggesting
as a new biomarker for BC prognosis. Considering currently available limited evidence, further studies need to be performed to investigate the roles of
in BC.
