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Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium
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Journal Article
Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium
2022
Overview
Bioactivity-guided separation of the methanol extract of
Calophyllum scriblitifolium
bark led to the isolation of five new pyranocoumarins, caloforines A–E (
1
–
5
) and two new coumarins, caloforines F and G (
6
and
7
). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A–F (
1
–
6
) showed moderate antimalarial activity against
Plasmodium falciparum
3D7 strain.
Graphical abstract
Publisher
Springer Nature Singapore,Springer Nature B.V
