Asset Details
Do you wish to reserve the book?
A genome-wide association scan for asthma in a general Australian population
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A genome-wide association scan for asthma in a general Australian population
Do you wish to request the book?
A genome-wide association scan for asthma in a general Australian population
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A genome-wide association scan for asthma in a general Australian population
2008
Overview
To date, almost every chromosome has been implicated in genetic susceptibility to asthma to some degree. When compared with single nucleotide polymorphism, microsatellite markers exhibit high levels of heterozygosity and therefore provide higher statistical power in association. The objective of this study was to perform a genome-wide association study using 23,465 in-house microsatellite markers to detect asthma susceptibility regions in the Busselton population. In this study, three separate pooled DNA screenings yielded 18 markers with significantly different estimated frequencies in the three separate “case and control” pools: each pool consisting of 60 males and 60 females. These markers were evaluated by individual typing in 360 cases and 360 controls. Two markers showed significant differences between cases and controls (
P
= 0.001 and
P
= 0.003). Regions surrounding the two markers were subjected to high-density association mapping with a total of 14 additional markers. We were able to confirm and fine map the association in these two regions by typing 14 additional microsatellite markers (1805A09 (D18S0325i),
P
= 0.002; 1806D05 (D18S0181i),
P
= 0.001). Each region contains a predicted gene that showed strong associations with asthma. Further studies are underway to characterize the novel candidate asthma susceptibility genes identified in this genome-wide study.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Asthma
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Chromosomes, Human, Pair 18 - genetics
/ Chronic obstructive pulmonary disease, asthma
/ Classical genetics, quantitative genetics, hybrids
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Genetic Predisposition to Disease
/ Genetics of eukaryotes. Biological and molecular evolution
/ Genomes
/ Genomics
/ Genotype
/ Human
/ Humans
/ Male
/ Microsatellite Repeats - genetics
/ Polymorphism, Single Nucleotide - genetics
