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Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

by Palmieri, Vincenzo O , Morini, Lorenzo , Spinzi, Giancarlo , Kosoy, Roman , Gregersen, Peter K , Rosina, Floriano , Marra, Fabio , Casella, Giovanni , Peltekian, Kevork M , Bernuzzi, Francesca , Niro, Grazia , Muratori, Paolo , Rossi, Sonia , Amos, Christopher I , Rigamonti, Cristina , Bianchi, Ilaria , Ghent, Cameron N , Myers, Robert P , Invernizzi, Pietro , Muratori, Luigi , Heathcote, E Jenny , Andreone, Pietro , Lee, Annette T , Siminovitch, Katherine A , Podda, Mauro , Mattalia, Alberto , Xie, Gang , Strazzabosco, Mario , Gershwin, M Eric , Liu, Xiangdong , Colombo, Silvia , Marzioni, Marco , Lu, Yan , Benedetti, Antonio , Xu, Chun , Bragazzi, Maria C , Lleo, Ana , Colli, Agostino , Alvaro, Domenico , Borghesio, Elisabetta , Hirschfield, Gideon M , Fabris, Luca , Picciotto, Antonio , Andriulli, Angelo , Galli, Andrea , Lazzari, Roberta , Lupoli, Sara , Floreani, Annarosa , Shigeta, Russell , Lu, Yue , Toniutto, Pierluigi , Seldin, Michael F , Vinci, Maria , Montanari, Renzo , Bruno, Savino , Macciardi, Fabio , Zuin, Massimo , Tiribelli, Claudio , Caporaso, Nicola , Mason, Andrew L , Prisco, Cleofe , Margotti, Marzia , Pisano, Alessandro , Croce, Lory , Colombo, Massim

in 631/208/205/2138 / 631/208/727/2000 / 692/699/1503/1607/1606 / Agriculture / Alleles / Animal Genetics and Genomics / Autoantibodies / Autoimmune diseases / Autoimmunity / Biliary cirrhosis / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / brief-communication / Canada / Cancer Research / Celiac disease / Chromosome mapping / Development and progression / Disease / Fundamental and applied biological sciences. Psychology / Gastroenterology. Liver. Pancreas. Abdomen / Gene Function / Genetic aspects / Genetics of eukaryotes. Biological and molecular evolution / Genome / Genome-Wide Association Study / Genomics / Human Genetics / Humans / Interferon Regulatory Factors / Liver Cirrhosis, Biliary / Liver. Biliary tract. Portal circulation. Exocrine pancreas / Medical research / Medical sciences / Meta-Analysis as Topic / Methods / Odds Ratio / Other diseases. Semiology / Properties / White People - genetics

2010

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Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

2010

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2010

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Journal Article

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Palmieri, Vincenzo O,

Morini, Lorenzo,

Spinzi, Giancarlo,

Kosoy, Roman,

Gregersen, Peter K,

Rosina, Floriano,

Marra, Fabio,

Casella, Giovanni,

Peltekian, Kevork M,

Bernuzzi, Francesca,

Niro, Grazia,

Muratori, Paolo,

Rossi, Sonia,

Amos, Christopher I,

Rigamonti, Cristina,

Bianchi, Ilaria,

Ghent, Cameron N,

Myers, Robert P,

Invernizzi, Pietro,

Muratori, Luigi,

Heathcote, E Jenny,

Andreone, Pietro,

Lee, Annette T,

Siminovitch, Katherine A,

Podda, Mauro,

Mattalia, Alberto,

Xie, Gang,

Strazzabosco, Mario,

Gershwin, M Eric,

Liu, Xiangdong,

Colombo, Silvia,

Marzioni, Marco,

Lu, Yan,

Benedetti, Antonio,

Xu, Chun,

Bragazzi, Maria C,

Lleo, Ana,

Colli, Agostino,

Alvaro, Domenico,

Borghesio, Elisabetta,

Hirschfield, Gideon M,

Fabris, Luca,

Picciotto, Antonio,

Andriulli, Angelo,

Galli, Andrea,

Lazzari, Roberta,

Lupoli, Sara,

Floreani, Annarosa,

Shigeta, Russell,

Lu, Yue,

Toniutto, Pierluigi,

Seldin, Michael F,

Vinci, Maria,

Montanari, Renzo,

Bruno, Savino,

Macciardi, Fabio,

Zuin, Massimo,

Tiribelli, Claudio,

Caporaso, Nicola,

Mason, Andrew L,

Prisco, Cleofe,

Margotti, Marzia,

Pisano, Alessandro,

Croce, Lory,

Colombo, Massim

2010

Overview

Michael Seldin and colleagues report a genome-wide association study and meta-analyses for primary biliary cirrhosis. They identify three loci newly associated with susceptibility to this autoimmune liver disease. A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB ( P = 7.9 × 10 −11 , odds ratio (OR) = 1.46), IRF5 - TNPO3 ( P = 2.8 × 10 −10 , OR = 1.63) and 17q12-21 ( P = 1.7 × 10 −10 , OR = 1.38).

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

631/208/205/2138

/ 631/208/727/2000

/ 692/699/1503/1607/1606

/ Agriculture

/ Alleles

/ Animal Genetics and Genomics

/ Autoantibodies