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Timing of Antiviral Treatment Initiation is Critical to Reduce SARS‐CoV‐2 Viral Load
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Timing of Antiviral Treatment Initiation is Critical to Reduce SARS‐CoV‐2 Viral Load
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Journal Article
Timing of Antiviral Treatment Initiation is Critical to Reduce SARS‐CoV‐2 Viral Load
2020
Overview
We modeled the viral dynamics of 13 untreated patients infected with severe acute respiratory syndrome‐coronavirus 2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than two logs, drug efficacy needs to be > 90% if treatment is administered after symptom onset; an efficacy of 60% could be sufficient if treatment is initiated before symptom onset. Given their pharmacokinetic/pharmacodynamic properties, current investigated drugs may be in a range of 6–87% efficacy. They may help control virus if administered very early, but may not have a major effect in severely ill patients.
Publisher
John Wiley & Sons, Inc,American Society for Clinical Pharmacology and Therapeutics ; International Society of Pharmacometrics,Wiley,John Wiley and Sons Inc
