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A randomized controlled trial on the effect of cranial electrotherapy stimulation on depression, anxiety, and craving in addicted male patients undergoing methadone maintenance treatment
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A randomized controlled trial on the effect of cranial electrotherapy stimulation on depression, anxiety, and craving in addicted male patients undergoing methadone maintenance treatment
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A randomized controlled trial on the effect of cranial electrotherapy stimulation on depression, anxiety, and craving in addicted male patients undergoing methadone maintenance treatment
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Journal Article
A randomized controlled trial on the effect of cranial electrotherapy stimulation on depression, anxiety, and craving in addicted male patients undergoing methadone maintenance treatment
2024
Overview
Background
Addicted patients undergoing methadone maintenance treatment are prone to several complications and the risk of relapse.
Objective
The present study aims to investigate the effect of cranial electrotherapy stimulation on depression, anxiety, and craving in addicted male people undergoing methadone maintenance treatment.
Methods
This randomized controlled trial study was conducted on 60 male patients referred to Persia addiction treatment center between 2021 and 2022. Patients were randomly divided into two equal treatment and placebo groups. The treatment group received cranial electrotherapy stimulation intervention for 48 sessions of 30 min. Depression and anxiety were evaluated using the Hamilton questionnaire before and after the intervention, and the level of craving was also evaluated with the Federdi 2008 questionnaire.
Results
Comparing the level of depression and anxiety before and after the intervention in both treatment and placebo groups did not show any significant difference (
p
< 0.05). Craving after the intervention was significantly different in both groups and was lower in the treatment group compared to the placebo group (33.43 versus 42.17,
p
= 0.004). In the placebo group, the level of anxiety and depression, and in the treatment group, the level of depression, anxiety and craving for consumption decreased significantly after the intervention compared to before the intervention (
p
< 0.05).
Conclusion
Cranial electrotherapy stimulation did not have a significant effect on reducing the level of depression and anxiety of patients, but it is effective in the reduction of craving in addicted people undergoing methadone maintenance treatment.
Trial registration
This randomized clinical trial was registered on 2022/5/13 with clinical trial code of IRCT20210523051367N1.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adult
/ Anxiety
/ Cranial electrotherapy stimulation
/ Craving
/ Electric Stimulation Therapy - methods
/ Humans
/ Insomnia
/ Male
/ Medicine
/ Methadone maintenance treatment
/ Opiate Substitution Treatment - methods
/ Opiate Substitution Treatment - psychology
/ Opioid-Related Disorders - drug therapy
/ Opioid-Related Disorders - psychology
/ Opioid-Related Disorders - therapy
/ Patients
/ Placebos
/ Skull
