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The metabolome identity: basis for discovery of biomarkers in neurodegeneration
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The metabolome identity: basis for discovery of biomarkers in neurodegeneration
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Journal Article
The metabolome identity: basis for discovery of biomarkers in neurodegeneration
2019
Overview
Neurodegenerative disorders are often associated with cellular dysfunction caused by underlying protein-misfolding signalling. Numerous neuropathologies are diagnosed at late stage symptomatic changes which occur in response to these molecular malfunctions and treatment is often too late or restricted only to the slowing of further cell death. Important new strategies to identify early biomarkers with predictive value to intervene with disease progression at stages where cell dysfunction has not progressed irreversibly is of paramount importance. Thus, the identification of these markers presents an essential opportunity to identify and target disease pathways. This review highlights some important metabolic alterations detected in neurodegeneration caused by misfolded prion protein and discusses common toxicity pathways identified across different neurodegenerative diseases. Thus, having established some commonalities between various degenerative conditions, detectable metabolic changes may be of extreme value as an early diagnostic biomarker in disease.
Publisher
Wolters Kluwer India Pvt. Ltd,Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,MRC Toxicology Unit, University of Leicester, Lancaster Road, Leicester, UK,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
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