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Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells
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Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells
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Journal Article
Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells
2005
Overview
Evidence is presented that bone marrow (BM) in addition to CD45
positive
hematopoietic stem cells contains a rare population of heterogenous CD45
negative
nonhematopoietic tissue committed stem cells (TCSC). These nonhematopoietic TCSC (i) are enriched in population of CXCR4
+
CD34
+
AC133
+
lin
−
CD45
−
and CXCR4
+
Sca-1
+
lin
−
CD45
−
in humans and mice, respectively, (ii) display several markers of pluripotent stem cells (PSC) and (iii) as we envision are deposited in BM early in development. Thus, since BM contains versatile nonhematopoietic stem cells, previous studies on plasticity
trans
-dedifferentiation of BM-derived hematopoietic stem cells (HSC) that did not include proper controls to exclude this possibility could lead to wrong interpretations. Therefore, in this spotlight review we present this alternative explanation of ‘plasticity’ of BM-derived stem cells based on the assumption that BM stem cells are heterogenous. We also discuss a potential relationship of TCSC/PSC identified by us with other BM-derived CD45
negative
nonhematopoietic stem cells that were recently identified by other investigators (eg MSC, MAPC, USSC and MIAMI cells). Finally, we discuss perspectives and pitfalls in potential application of these cells in regenerative medicine.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
