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Mechanism of Action and Biology of Flow Diverters in the Treatment of Intracranial Aneurysms
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Mechanism of Action and Biology of Flow Diverters in the Treatment of Intracranial Aneurysms
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Journal Article
Mechanism of Action and Biology of Flow Diverters in the Treatment of Intracranial Aneurysms
2020
Overview
Abstract
Flow diverters have drastically changed the landscape of intracranial aneurysm treatment and are now considered first-line therapy for select lesions. Their mechanism of action relies on intrinsic alteration in hemodynamic parameters, both at the parent artery and within the aneurysm sac. Moreover, the device struts act as a nidus for endothelial cell growth across the aneurysm neck ultimately leading to aneurysm exclusion from the circulation. In silico computational analyses and investigations in preclinical animal models have provided valuable insights into the underlying biological basis for flow diverter therapy. Here, we review the present understanding pertaining to flow diverter biology and mechanisms of action, focusing on stent design, induction of intra-aneurysmal thrombosis, endothelialization, and alterations in hemodynamics.
Publisher
Oxford University Press,Copyright by the Congress of Neurological Surgeons,Wolters Kluwer Health, Inc
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