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Serum cystatin C levels are negatively correlated with post-stroke cognitive dysfunction
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Journal Article
Serum cystatin C levels are negatively correlated with post-stroke cognitive dysfunction
2020
Overview
Stroke is the leading cause of death and long-term disability worldwide, and cognitive impairment and dementia are major complications of ischemic stroke. Cystatin C (CysC) has been found to be a neuroprotective factor in animal studies. However, the relationship between CysC levels and cognitive dysfunction in previous studies has revealed different results. This prospective observational study investigated the correlation between serum CysC levels and post-stroke cognitive dysfunction at 3 months. Data from 638 patients were obtained from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). Cognitive dysfunction was assessed using the Mini-Mental State Examination (MMSE) at 3 months after stroke. According to the MMSE score, 308 patients (52.9%) had post-stroke cognitive dysfunction. After adjusting for potential confounding factors, the odds ratio (95% CI) of post-stroke cognitive dysfunction for the highest quartile of serum CysC levels was 0.54 (0.30-0.98), compared with the lowest quartile. The correlation between serum CysC and cognitive dysfunction was modified by renal function status. We observed a negative linear dose-response correlation between CysC and cognitive dysfunction in patients with normal renal function (Plinearity = 0.044), but not in those with abnormal renal function. Elevated serum CysC levels were correlated with a low risk of 3-month cognitive dysfunction in patients with acute ischemic stroke, especially in those with normal renal function. The current results suggest that CysC is a protective factor for post-stroke cognitive dysfunction, and could be used to treat post-stroke cognitive dysfunction. The CATIS study was approved by the Institutional Review Boards at Soochow University from China (approval No. 2012-02) on December 30, 2012, and was registered at ClinicalTrials.gov (identifier No. NCT01840072) on April 25, 2013.
Publisher
Wolters Kluwer India Pvt. Ltd,Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA%Department of Neurology, Siping Central Hospital, Siping, Jilin Province, China%Department of Neurology, the 88th Hospital of People's Liberation Army, Taian, Shandong Province, China%Department of Internal Medicine, Feicheng City People's Hospital, Feicheng, Shandong Province, China%Department of Neurology, Tongliao Municipal Hospital, Inner Mongolia Autonomous Region, China%Department of Neurology, Kerqin District First People's Hospital of Tongliao City, Inner Mongolia Autonomous Region, China%Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA%Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA,Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA,Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu Province, China%Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu Province, China,Wolters Kluwer - Medknow,Wolters Kluwer Medknow Publications
