Asset Details
Do you wish to reserve the book?
ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model
Do you wish to request the book?
ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model
2009
Overview
Background
We examined whether impaired renal function causes thickening of the aortic valve leaflets in hyperlipidemic apoE-knockout (apoE
-/-
) mice, and whether the putative effect on the aortic valves could be prevented by inhibiting the angiotensin-converting enzyme (ACE) with enalapril.
Methods
Thickening of the aortic valve leaflets in apoE
-/-
mice was induced by producing mild or moderate chronic renal failure resulting from unilateral nephrectomy (1/2 NX, n = 18) or subtotal nephrectomy (5/6 NX, n = 22), respectively. Additionally, the 5/6 NX mice were randomized to no treatment (n = 8) or enalapril treatment (n = 13). The maximal thickness of each leaflet was measured from histological sections of the aortic roots.
Results
Leaflet thickness was significantly greater in the 5/6 NX mice than in the 1/2 NX mice (P = 0.030) or the unoperated mice (P = 0.003). The 5/6 NX mice treated with enalapril had significantly thinner leaflets than did the untreated 5/6 NX mice (P = 0.014).
Conclusion
Moderate uremia causes thickening of the aortic valves in apoE
-/-
mice, which can be attenuated by ACE inhibition. The nephrectomized apoE
-/-
mouse constitutes a new model for investigating the mechanisms of uremia-induced aortic valve disease, and also provides an opportunity to study its pharmacologic prevention.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Angiotensin-Converting Enzyme Inhibitors - administration & dosage
/ Animals
/ Aortic Valve Stenosis - blood
/ Aortic Valve Stenosis - drug therapy
/ Aortic Valve Stenosis - etiology
/ Aortic Valve Stenosis - physiopathology
/ Apolipoproteins E - deficiency
/ Complications and side effects
/ Enalapril - administration & dosage
/ Male
/ Medicine
/ Mice
/ Renal Insufficiency - complications
/ Renal Insufficiency - physiopathology
/ Renin-Angiotensin System - drug effects
/ Uremia
