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Electrochemotherapy: from the drawing board into medical practice
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Journal Article
Electrochemotherapy: from the drawing board into medical practice
2014
Overview
Electrochemotherapy is a local treatment of cancer employing electric pulses to improve transmembrane transfer of cytotoxic drugs. In this paper we discuss electrochemotherapy from the perspective of biomedical engineering and review the steps needed to move such a treatment from initial prototypes into clinical practice. In the paper also basic theory of electrochemotherapy and preclinical studies
in vitro
and
in vivo
are briefly reviewed. Following this we present a short review of recent clinical publications and discuss implementation of electrochemotherapy into standard of care for treatment of skin tumors, and use of electrochemotherapy for other targets such as head and neck cancer, deep-seated tumors in the liver and intestinal tract, and brain metastases. Electrodes used in these specific cases are presented with their typical voltage amplitudes used in electrochemotherapy. Finally, key points on what should be investigated in the future are presented and discussed.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V
Subject
Antineoplastic Agents - administration & dosage
/ Biomedical Engineering - methods
/ Biomedical Engineering and Bioengineering
/ Biomedical Engineering/Biotechnology
/ Brain Neoplasms - drug therapy
/ Cancer
/ Design
/ Electrochemotherapy - methods
/ Electrochemotherapy - standards
/ Humans
/ Methods
/ Review
/ Skin Neoplasms - drug therapy
/ Tumors
