Asset Details
Do you wish to reserve the book?
A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen
Do you wish to request the book?
A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen
2019
Overview
About the Authors: Nicholas Raffa Affiliation: Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America ORCID logo http://orcid.org/0000-0003-0112-5262 Nancy P. Keller * E-mail: npkeller@wisc.edu Affiliations Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America ORCID logo http://orcid.org/0000-0002-4386-9473 Introduction Aspergillus fumigatus is a ubiquitous saprophytic mold able to grow on a diversity of material ranging from decayed organic matter in the environment to space station cupolas [1]. The compound displays activity against Toxoplasma gondii and Trypanosoma cruzi in vitro that causes toxoplasmosis and Chagas disease, respectively. Helvolic acid Helvolic acid is a fusidane antibiotic that exhibits in vitro antiprotozoal activity against the trypanosome Trypanosoma brucei brucei GUTat3.1, the causative agent of African sleeping sickness [29], and helvolic acid derivatives exhibit antibacterial activity against Streptococcus agalactiae and Staphylococcus aureus [30]. Macheleidt J, Scherlach K, Neuwirth T, Schmidt‐Heck W, Straßburger M, Spraker J, Baccile JA, Schroeder FC, Keller NP, Hertweck C, Heinekamp T. Transcriptome analysis of cyclic AMP‐dependent protein kinase A–regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Anti-Bacterial Agents - pharmacology
/ Aspergillosis - drug therapy
/ Aspergillosis - microbiology
/ Aspergillus fumigatus - drug effects
/ Cupolas
/ Fungi
/ Genes
/ Host-Pathogen Interactions - drug effects
/ Humans
/ Kinases
/ Medicine and Health Sciences
/ Mycoses
/ Opportunistic Infections - etiology
/ Opportunistic Infections - metabolism
/ Opportunistic Infections - pathology
/ Pearls
/ Roles
