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Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
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Journal Article
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
2008
Overview
Jason Cooper and colleagues identify four new risk loci for type 1 diabetes through a meta-analysis of data from three genome-wide association studies, with replication in additional case-control and family-based samples, providing further insights into the genetic risk factors underlying this disease.
We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (
IL2-IL21
,
P
= 1.9 × 10
−8
) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (
BACH2
,
P
= 4.7 × 10
−12
), 10p15 (
PRKCQ
,
P
= 3.7 × 10
−9
), 15q24 (
CTSH
,
P
= 3.2 × 10
−15
) and 22q13 (
C1QTNF6
,
P
= 2.0 × 10
−8
).
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animal Genetics and Genomics
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Diabetes Mellitus, Type 1 - genetics
/ Diabetes. Impaired glucose tolerance
/ Endocrine pancreas. Apud cells (diseases)
/ Etiopathogenesis. Screening. Investigations. Target tissue resistance
/ Fundamental and applied biological sciences. Psychology
/ Genetic Predisposition to Disease
/ Genetics of eukaryotes. Biological and molecular evolution
/ Genome-Wide Association Study
/ Humans
/ Polymorphism, Single Nucleotide
