Asset Details
Do you wish to reserve the book?
Monocytes in atherosclerosis: subsets and functions
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Monocytes in atherosclerosis: subsets and functions
Do you wish to request the book?
Monocytes in atherosclerosis: subsets and functions
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Monocytes in atherosclerosis: subsets and functions
2010
Overview
Plaque macrophages account for the majority of leukocytes in atherosclerotic plaques, and are believed to differentiate from monocytes recruited from circulating blood. In this Review, Dr Woollard and Dr Geissmann discuss the heterogenous population of monocytes involved in the pathogenesis of atherosclerosis.
Chronic inflammation drives atherosclerosis, the leading cause of cardiovascular disease. Over the past two decades, data have emerged showing that immune cells are involved in the pathogenesis of atherosclerotic plaques. The accumulation and continued recruitment of leukocytes are associated with the development of 'vulnerable' plaques. These plaques are prone to rupture, leading to thrombosis, myocardial infarction or stroke, all of which are frequent causes of death. Plaque macrophages account for the majority of leukocytes in plaques, and are believed to differentiate from monocytes recruited from circulating blood. However, monocytes represent a heterogenous circulating population of cells. Experiments are needed to address whether monocyte recruitment to plaques and effector functions, such as the formation of foam cells, the production of nitric oxide and reactive oxygen species, and proteolysis are critical for the development and rupture of plaques, and thus for the pathophysiology of atherosclerosis, as well as elucidate the precise mechanisms involved.
Key Points
Atherosclerosis has long been associated with chronic inflammation
The accumulation of macrophages correlates with atherosclerotic plaque progression and plaque rupture
Monocytes accumulate at sites of inflammation and have been reported to enter atherosclerotic plaques
Macrophages and foam cell are present in plaques and might derive from monocytes or from resident macrophages
Monocytes represent a heterogeneous population of cells with differences in phenotype, function and locomotion
Publisher
Nature Publishing Group UK,Nature Publishing Group
