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Decline in the Cumulative Incidence of Severe Diabetic Retinopathy in Patients With Type 1 Diabetes
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Decline in the Cumulative Incidence of Severe Diabetic Retinopathy in Patients With Type 1 Diabetes
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Journal Article
Decline in the Cumulative Incidence of Severe Diabetic Retinopathy in Patients With Type 1 Diabetes
2011
Overview
To determine if the cumulative incidence of severe retinopathy in patients with type 1 diabetes has changed.
The study looked at 3,781 patients diagnosed with type 1 diabetes (1939-2005), median age at onset 13 (interquartile range [IQR] 9-21) years, and duration of diabetes 19 (IQR 13-27) years. The severe retinopathy was based on a history of laser treatment. Patients were divided into <1975, 1975-1979, 1980-1984, and ≥1985 cohorts according to the diagnosis of diabetes.
The cumulative incidence of severe retinopathy has declined (P < 0.0001). After 20 years of duration, the cumulative incidence was 23% (95% CI 21-25) and 33 (30-35) in the earliest cohorts, 18 (15-21) in the next cohort, and 6 (4-9) in the recent cohort. After 30 years, the cumulative incidence was 52 and 48% in the earliest cohorts, while it was 62% after 40 years in the earliest cohort.
The cumulative incidence of severe retinopathy has declined in patients with type 1 diabetes.
Publisher
American Diabetes Association
Subject
/ Adult
/ Biological and medical sciences
/ Child
/ Diabetes
/ Diabetes Mellitus, Type 1 - complications
/ Diabetes Mellitus, Type 1 - epidemiology
/ Diabetes. Impaired glucose tolerance
/ Diabetic Retinopathy - epidemiology
/ Diabetic Retinopathy - etiology
/ Endocrine pancreas. Apud cells (diseases)
/ etiology
/ Etiopathogenesis. Screening. Investigations. Target tissue resistance
/ Female
/ Humans
/ insulin-dependent diabetes mellitus
/ Male
/ patients
/ Public health. Hygiene-occupational medicine
/ Studies
