Journal Article

Integrated collaborative care for comorbid major depression in patients with cancer (SMaRT Oncology-2): a multicentre randomised controlled effectiveness trial

Wall, Lucy, Martin, Paul, Weller, David, Murray, Gordon, Sharpe, Michael, Hansen, Christian Holm, Symeonides, Stefan, Walker, Jane, Gourley, Charlie

2014

Overview

Medical conditions are often complicated by major depression, with consequent additional impairment of quality of life. We aimed to compare the effectiveness of an integrated treatment programme for major depression in patients with cancer (depression care for people with cancer) with usual care. SMaRT Oncology-2 is a parallel-group, multicentre, randomised controlled effectiveness trial. We enrolled outpatients with major depression from three cancer centres and their associated clinics in Scotland, UK. Participants were randomly assigned in a 1:1 ratio to the depression care for people with cancer intervention or usual care, with stratification (by trial centre) and minimisation (by age, primary cancer, and sex) with allocation concealment. Depression care for people with cancer is a manualised, multicomponent collaborative care treatment that is delivered systematically by a team of cancer nurses and psychiatrists in collaboration with primary care physicians. Usual care is provided by primary care physicians. Outcome data were collected up until 48 weeks. The primary outcome was treatment response (≥50% reduction in Symptom Checklist Depression Scale [SCL-20] score, range 0–4) at 24 weeks. Trial statisticians and data collection staff were masked to treatment allocation, but participants could not be masked to the allocations. Analyses were by intention to treat. This trial is registered with Current Controlled Trials, number ISRCTN40568538. 500 participants were enrolled between May 12, 2008, and May 13, 2011; 253 were randomly allocated to depression care for people with cancer and 247 to usual care. 143 (62%) of 231 participants in the depression care for people with cancer group and 40 (17%) of 231 in the usual care group responded to treatment: absolute difference 45% (95% CI 37–53), adjusted odds ratio 8·5 (95% CI 5·5–13·4), p<0·0001. Compared with patients in the usual care group, participants allocated to the depression care for people with cancer programme also had less depression, anxiety, pain, and fatigue; and better functioning, health, quality of life, and perceived quality of depression care at all timepoints (all p<0·05). During the study, 34 cancer-related deaths occurred (19 in the depression care for people with cancer group, 15 in the usual care group), one patient in the depression care for people with cancer group was admitted to a psychiatric ward, and one patient in this group attempted suicide. None of these events were judged to be related to the trial treatments or procedures. Our findings suggest that depression care for people with cancer is an effective treatment for major depression in patients with cancer. It offers a model for the treatment of depression comorbid with other medical conditions. Cancer Research UK and Chief Scientist Office of the Scottish Government.

• Publisher: Elsevier Ltd,Elsevier,Elsevier Limited
• Subject: Adult / Adult and adolescent clinical studies / Aged / Aged, 80 and over / Analysis of Variance / Antidepressants / Antidepressive Agents - therapeutic use / Biological and medical sciences / Cancer / Cancer therapies / Comorbidity / Data collection / Delivery of Health Care, Integrated / Depression / Depressive Disorder, Major - psychology / Depressive Disorder, Major - therapy / Female / General aspects / Humans / Internal Medicine / Male / Medical personnel / Medical prognosis / Medical sciences / Mental depression / Mental health / Middle Aged / Mood disorders / Multiple tumors. Solid tumors. Tumors in childhood (general aspects) / Neoadjuvant Therapy / Neoplasms - psychology / Neoplasms - therapy / Oncology / Patient Acceptance of Health Care - statistics & numerical data / Patient Care Team / Patients / Primary care / Psychology. Psychoanalysis. Psychiatry / Psychopathology. Psychiatry / Psychotherapy - statistics & numerical data / Quality of life / Suicide / Treatment Outcome / Tumors / Young Adult