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Impact of childhood trauma on sensory gating in patients with first-episode schizophrenia
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Impact of childhood trauma on sensory gating in patients with first-episode schizophrenia
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Impact of childhood trauma on sensory gating in patients with first-episode schizophrenia
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Journal Article
Impact of childhood trauma on sensory gating in patients with first-episode schizophrenia
2018
Overview
Background
Childhood trauma (CT) has been found to contribute to the onset of schizophrenia and auditory sensory gating deficit is a leading endophenotype for schizophrenia. However, the association between the CT and sensory gating in first-episode schizophrenia remains elusive.
Methods
Fifty-six patients and 49 age and sex-matched healthy controls were assessed using the Childhood Trauma Questionnaire-Short Form (CTQ-SF) for CT and Positive and Negative Syndrome Scale (PANSS) for symptoms severity. Sensory gating was tested using the modified paradigm, perceived spatial separation-induced prepulse inhibition (PSS-PPI), and the perceived spatial co-location PPI (PSC-PPI or classical PPI).
Results
Comparing with healthy controls, the patients had significantly higher score on sexual abuse (
t
= 2.729,
p
< 0.05), lower PSS- PPI, % (ISI = 120 ms and ISI = 60 ms) (
t
= − 3.089, − 4.196,
p
< 0.05). Univariate analysis revealed the absence of a significant correlation among CT, PPI paradigms and symptoms. However, multiple linear regression analyses demonstrated the CTQ-SF total was negatively associated with PSS PPI (ISI = 120 ms) (
p
= 0.018).
Conclusion
The current study illustrates that the impact of CT on sensory gating in patients with first-episode schizophrenia, and thus we conclude that CT may be a risk factor to the occurrence of schizophrenia through its impact on sensory gating.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
