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Triggering final follicular maturation for IVF cycles
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Journal Article
Triggering final follicular maturation for IVF cycles
2025
Overview
As part of a conventional controlled ovarian hyperstimulation (COH) regimen, final follicular maturation is usually triggered by a single bolus dose of human chorionic gonadotropin (hCG). COH, which combines GnRH antagonist co-treatment with GnRH agonist(GnRHa) trigger, is often used in attempts to eliminate severe early ovarian hyperstimulation syndrome and to improve oocyte/embryo yield and quality. Recently, the combination of GnRHa, with hCG trigger has also been implemented into clinical practice. Here, we analyze and discuss published studies on various ways of triggering final follicular maturation, seeking to elucidate the appropriateness of each approach for specific patient subgroups.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Chorionic Gonadotropin - administration & dosage
/ Chorionic Gonadotropin - therapeutic use
/ Controlled ovarian hyperstimulation
/ Embryos
/ Female
/ Fertilization in Vitro - methods
/ Gonadotropin-releasing hormone
/ Gonadotropin-Releasing Hormone - agonists
/ Gonadotropin-Releasing Hormone - antagonists & inhibitors
/ hCG
/ Humans
/ Medicine
/ OHSS
/ Ovarian Follicle - drug effects
/ Ovarian Follicle - physiology
/ Ovarian hyperstimulation syndrome
/ Ovarian Hyperstimulation Syndrome - prevention & control
/ Ovaries
/ Ovulation Induction - methods
/ Review
