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Long-term (5-year) antibody persistence following two- and three-dose regimens of a combined hepatitis A and B vaccine in children aged 1–11 years
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Long-term (5-year) antibody persistence following two- and three-dose regimens of a combined hepatitis A and B vaccine in children aged 1–11 years
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Long-term (5-year) antibody persistence following two- and three-dose regimens of a combined hepatitis A and B vaccine in children aged 1–11 years
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Journal Article
Long-term (5-year) antibody persistence following two- and three-dose regimens of a combined hepatitis A and B vaccine in children aged 1–11 years
2010
Overview
This study compared the long-term persistence of anti-hepatitis A (anti-HAV) and B (anti-HBs) antibodies, 5 years after vaccination of subjects aged 1–11 years with a combined hepatitis A and B vaccine either in a two-dose (0, 6 months,
Adult formulation) or a three-dose (0, 1, 6 months,
Paediatric formulation) schedule. At the end of the 5 years, all subjects (100%) in both groups continued to have anti-HAV antibodies ≥15
mIU/mL, while 94–97% of subjects in both groups had anti-HBs antibody concentrations ≥10
mIU/mL. Subjects with anti-HBs antibody concentration ≤10
mIU/mL were administered a challenge dose of hepatitis B vaccine. All subjects mounted a vigorous immune response to the challenge indicating the presence of immunological memory to HBV.
Publisher
Elsevier Ltd,Elsevier,Elsevier Limited
Subject
/ Biological and medical sciences
/ Child
/ Combined
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Hepatitis A Vaccines - administration & dosage
/ Hepatitis A Vaccines - immunology
/ Hepatitis B Antibodies - blood
/ Hepatitis B Antibodies - immunology
/ Hepatitis B Vaccines - administration & dosage
/ Hepatitis B Vaccines - immunology
/ Humans
/ Infant
/ Licenses
/ Male
/ MEDICIN
/ MEDICINE
/ Vaccines
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
