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Association between cognitive impairment and motor dysfunction among patients with multiple sclerosis: a cross-sectional study
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Association between cognitive impairment and motor dysfunction among patients with multiple sclerosis: a cross-sectional study
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Association between cognitive impairment and motor dysfunction among patients with multiple sclerosis: a cross-sectional study
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Journal Article
Association between cognitive impairment and motor dysfunction among patients with multiple sclerosis: a cross-sectional study
2023
Overview
Background
Previous studies have shown that there is a relationship between cognitive impairment (CI) and motor dysfunction (MD) in neurological diseases, such as Alzheimer’s and Parkinson’s disease. However, there whether CI and MD are associated in patients with multiple sclerosis (MS) is unknown. Here we studied the association between CI and MD in patients with MS and examined if muscle weakness or incoordination, balance impairment, gait abnormalities, and/or increased fall risk are indicators of CI in patients with MS.
Methods
Seventy patients with MS were included in this cross-sectional study. Cognitive impairment was assessed using the Montreal Cognitive Assessment Scale (MoCA), muscle strength using a hand-held dynamometer, and balance, gait, and fall risk assessment using the Tinetti scale. Motor coordination was assessed using the timed rapid alternating movement test for the upper extremity and the timed alternate heel-to-knee test for the lower extremity.
Results
There was a significant association between CI and motor coordination, balance, gait, and risk of fall (
p
< 0.005) but not muscle strength. Stepwise multiple linear regression showed that 22.7% of the variance in the MoCA was predicted by the fall risk and incoordination of the upper extremities in the MS population.
Conclusions
CI is significantly associated with motor incoordination, balance impairment, gait abnormality, and increased fall risk. Furthermore, the risk of fall and upper extremity incoordination appeared to be best indicators of CI in patients with MS.
