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Carbon ion radiation therapy in breast cancer: a new frontier
by
Mahajan, Anita
, Mutter, Robert W.
, Trifiletti, Daniel M.
, Krishnan, Sunil
, Malouff, Timothy D.
, Hoppe, Bradford S.
, Beltran, Chris
, Vallow, Laura A.
in
Breast cancer
/ Breast Neoplasms - pathology
/ Breast Neoplasms - radiotherapy
/ Cancer
/ Cancer research
/ Cancer therapies
/ Carbon
/ Care and treatment
/ Clinical trials
/ Female
/ Health aspects
/ Heavy Ion Radiotherapy - methods
/ Humans
/ Medicine
/ Medicine & Public Health
/ Oncology
/ Prognosis
/ Radiation
/ Radiation therapy
/ Radiotherapy
/ Review
/ Reviews
/ Toxicity
2020
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Carbon ion radiation therapy in breast cancer: a new frontier
by
Mahajan, Anita
, Mutter, Robert W.
, Trifiletti, Daniel M.
, Krishnan, Sunil
, Malouff, Timothy D.
, Hoppe, Bradford S.
, Beltran, Chris
, Vallow, Laura A.
in
Breast cancer
/ Breast Neoplasms - pathology
/ Breast Neoplasms - radiotherapy
/ Cancer
/ Cancer research
/ Cancer therapies
/ Carbon
/ Care and treatment
/ Clinical trials
/ Female
/ Health aspects
/ Heavy Ion Radiotherapy - methods
/ Humans
/ Medicine
/ Medicine & Public Health
/ Oncology
/ Prognosis
/ Radiation
/ Radiation therapy
/ Radiotherapy
/ Review
/ Reviews
/ Toxicity
2020
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Do you wish to request the book?
Carbon ion radiation therapy in breast cancer: a new frontier
by
Mahajan, Anita
, Mutter, Robert W.
, Trifiletti, Daniel M.
, Krishnan, Sunil
, Malouff, Timothy D.
, Hoppe, Bradford S.
, Beltran, Chris
, Vallow, Laura A.
in
Breast cancer
/ Breast Neoplasms - pathology
/ Breast Neoplasms - radiotherapy
/ Cancer
/ Cancer research
/ Cancer therapies
/ Carbon
/ Care and treatment
/ Clinical trials
/ Female
/ Health aspects
/ Heavy Ion Radiotherapy - methods
/ Humans
/ Medicine
/ Medicine & Public Health
/ Oncology
/ Prognosis
/ Radiation
/ Radiation therapy
/ Radiotherapy
/ Review
/ Reviews
/ Toxicity
2020
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Carbon ion radiation therapy in breast cancer: a new frontier
Journal Article
Carbon ion radiation therapy in breast cancer: a new frontier
2020
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Overview
Purpose
Breast cancer is the most commonly diagnosed cancer in women, with many efforts aimed at reducing acute and late toxicity given the generally favorable clinical outcomes with the current standard of care. Carbon ion radiation therapy is an emerging technique that may reduce dose to adjacent organs at risk while allowing dose escalation to the target. Given the efficacy of the standard treatments for breast cancer, there have been few prospective studies to date investigating carbon ion radiation therapy in breast cancer.
Methods
PubMed/Medline, Ebsco, Cochrane, and Scopus were systematically reviewed using the search terms “carbon ion” and “breast” in November 2019. Out of the 76 articles screened, 26 articles were included.
Results
This comprehensive review describes the physical and biological properties of carbon ion radiation therapy, with an emphasis on how these properties can be applied in the setting of breast cancer. Studies investigating the role of carbon ion radiation therapy in early stage breast cancers are reviewed. Additionally, the use of carbon ion radiation therapy in locally advanced disease, recurrent disease, and radiation-induced angiosarcoma are discussed.
Conclusion
Although the data is limited, the early clinical results are promising. Further clinical trials are needed, especially in the setting of locally advanced and recurrent disease, to fully define the potential role of carbon ion radiation therapy in the treatment of breast cancer.
Publisher
Springer US,Springer,Springer Nature B.V
Subject
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