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MERS-CoV spike nanoparticles protect mice from MERS-CoV infection

by Smith, Gale E. , Frieman, Matthew B. , Liu, Ye V. , Venkataraman, Thiagarajan , Glenn, Gregory M. , Flyer, David C. , Coleman, Christopher M.

in Adenoviruses / adjuvants / Adjuvants, Immunologic - administration & dosage / Allergy and Immunology / Animals / Antibodies, Neutralizing - blood / Antibodies, Viral - blood / Colleges & universities / Coronaviridae / Coronavirus / Coronavirus Infections - prevention & control / Disease Models, Animal / Drug dosages / Experiments / Funding / Immunization / Immunoglobulins / Infections / Lungs / MERS-CoV / mice / Mice, Inbred BALB C / Middle East respiratory syndrome coronavirus / Middle East Respiratory Syndrome Coronavirus - genetics / Middle East Respiratory Syndrome Coronavirus - immunology / Mouse model / Nanoparticle vaccine / nanoparticles / neutralizing antibodies / Proteins / Respiratory diseases / Spike Glycoprotein, Coronavirus - genetics / Spike Glycoprotein, Coronavirus - immunology / vaccination / Vaccines / Vaccines, Synthetic - administration & dosage / Vaccines, Synthetic - genetics / Vaccines, Synthetic - immunology / Vaccines, Virus-Like Particle - administration & dosage / Vaccines, Virus-Like Particle - genetics / Vaccines, Virus-Like Particle - immunology / Viral Vaccines - administration & dosage / Viral Vaccines - genetics / Viral Vaccines - immunology / virion

2017

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MERS-CoV spike nanoparticles protect mice from MERS-CoV infection

by Smith, Gale E. , Frieman, Matthew B. , Liu, Ye V. , Venkataraman, Thiagarajan , Glenn, Gregory M. , Flyer, David C. , Coleman, Christopher M.

2017

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MERS-CoV spike nanoparticles protect mice from MERS-CoV infection

by Smith, Gale E. , Frieman, Matthew B. , Liu, Ye V. , Venkataraman, Thiagarajan , Glenn, Gregory M. , Flyer, David C. , Coleman, Christopher M.

2017

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Journal Article

MERS-CoV spike nanoparticles protect mice from MERS-CoV infection

Smith, Gale E.,

Frieman, Matthew B.,

Liu, Ye V.,

Venkataraman, Thiagarajan,

Glenn, Gregory M.,

Flyer, David C.,

Coleman, Christopher M.

2017

Overview

The Middle East respiratory syndrome coronavirus (MERS-CoV) was first discovered in late 2012 and has gone on to cause over 1800 infections and 650 deaths. There are currently no approved therapeutics or vaccinations for MERS-CoV. The MERS-CoV spike (S) protein is responsible for receptor binding and virion entry to cells, is immunodominant and induces neutralizing antibodies in vivo, all of which, make the S protein an ideal target for anti-MERS-CoV vaccines. In this study, we demonstrate protection induced by vaccination with a recombinant MERS-CoV S nanoparticle vaccine and Matrix-M1 adjuvant combination in mice. The MERS-CoV S nanoparticle vaccine produced high titer anti-S neutralizing antibody and protected mice from MERS-CoV infection in vivo.

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Publisher

Elsevier Ltd,Elsevier Limited

Subject

Adenoviruses

/ adjuvants

/ Adjuvants, Immunologic - administration & dosage

/ Allergy and Immunology

/ Animals

/ Antibodies, Neutralizing - blood

/ Antibodies, Viral - blood