Asset Details
Do you wish to reserve the book?
Neural tube defects: recent advances, unsolved questions, and controversies
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Neural tube defects: recent advances, unsolved questions, and controversies
Do you wish to request the book?
Neural tube defects: recent advances, unsolved questions, and controversies
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Neural tube defects: recent advances, unsolved questions, and controversies
2013
Overview
Neural tube defects are severe congenital malformations affecting around one in every 1000 pregnancies. An innovation in clinical management has come from the finding that closure of open spina bifida lesions in utero can diminish neurological dysfunction in children. Primary prevention with folic acid has been enhanced through introduction of mandatory food fortification in some countries, although not yet in the UK. Genetic predisposition accounts for most of the risk of neural tube defects, and genes that regulate folate one-carbon metabolism and planar cell polarity have been strongly implicated. The sequence of human neural tube closure events remains controversial, but studies of mouse models of neural tube defects show that anencephaly, open spina bifida, and craniorachischisis result from failure of primary neurulation, whereas skin-covered spinal dysraphism results from defective secondary neurulation. Other malformations, such as encephalocele, are likely to be postneurulation disorders.
Publisher
Elsevier Ltd,Elsevier Limited
Subject
/ Animals
/ Databases, Factual - statistics & numerical data
/ Fetuses
/ Folic Acid - therapeutic use
/ Genetic Predisposition to Disease
/ Humans
/ Methylenetetrahydrofolate Reductase (NADPH2) - genetics
/ Methylenetetrahydrofolate Reductase (NADPH2) - metabolism
/ Neural Tube Defects - epidemiology
/ Neural Tube Defects - etiology
/ Neural Tube Defects - genetics
/ Neural Tube Defects - therapy
/ Surgery
