Journal Article

Association between ambient particulate matter exposure and semen quality in fertile men

Tang, Naijun, Pan, Feng, Wu, Wei, Tang, Qiuqin, Sun, Zhiwei, London, Stephanie J., Chen, Yiqiu, Wang, Xinru, Cheng, Yuting, Xia, Yankai

2022

Overview

Background Several studies have suggested adverse effects of particulate matter (PM) exposure on male reproductive health; few have investigated the association between PM exposure and semen quality in a large population of fertile men. Methods We evaluated 14 parameters of semen quality in 1554 fertile men in Nanjing from 2014 to 2016. Individual exposure to particular matter ≤10 μm in diameter (PM 10 ) and ≤ 2.5 μm in diameter (PM 2.5 ) during key periods of sperm development (0-90, 0-9, 10-14, 15-69, and 70-90 days before semen collection) were estimated by inverse distance weighting interpolation. Associations between PM exposure and semen quality were estimated using multivariable linear regression. Results Higher 90-days average PM 2.5 was in association with decreased sperm motility (2.21% for total motility, 1.93% for progressive motility per 10 μg/m 3 increase, P  <  0.001) and four quantitative aspects of sperm motion (curvilinear velocity (VCL), straight line velocity (VSL), average path velocity (VAP), and amplitude of lateral head displacement (ALH), P  <  0.01). The association between PM 2.5 exposure and semen quality were generally stronger for the earlier exposure window (70-90 days prior to ejaculation) than for recent exposure (0-9, 10-14, or 15-69 days). In the subgroup of men who had normal sperm parameters ( n  = 1019), similar results were obtained. Ninety-days PM 10 exposure was associated only with decreased VCL and VAP and was not related to sperm concentration. Conclusions Exposure to PM 2.5 adversely affects semen quality, specifically lower sperm motility, in fertile men. Graphical abstract

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Air Pollutants - analysis / Air Pollutants - toxicity / Air pollution / Ambient air pollution / Body mass index / Earth and Environmental Science / Ejaculation / Environment / Environmental Epidemiology / Environmental Exposure - statistics & numerical data / Environmental Health / Ethnicity / Exposure / Family income / Fertility / Health aspects / Humans / Infertility / Infertility, Male / Interpolation / Lateral displacement / Male / Motility / Occupational Medicine/Industrial Medicine / Outdoor air quality / Parameters / Particles / Particulate emissions / Particulate matter / Particulate Matter - analysis / Particulate Matter - toxicity / PM10 / PM2.5 / Pollutants / Population / Public Health / Reproductive health / Risk factors / Semen / Semen Analysis / Semen quality / Smoking / Software / Sperm / Sperm Count / Sperm Motility / Spermatogenesis / Spermatozoa / Statistical analysis / Straight lines / Subgroups / Velocity / Womens health