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Pregnancy outcomes in pregnant women taking oral probiotic undergoing cerclage compared to placebo: two blinded randomized controlled trial
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Pregnancy outcomes in pregnant women taking oral probiotic undergoing cerclage compared to placebo: two blinded randomized controlled trial
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Journal Article
Pregnancy outcomes in pregnant women taking oral probiotic undergoing cerclage compared to placebo: two blinded randomized controlled trial
2024
Overview
Aim
The purpose of this study is to evaluate the oral probiotic effect on pregnancy outcomes in pregnant women undergoing cerclage compared to placebo.
Methods
This study was a double-blind randomized clinical trial undertaken in Yasuj, Iran. 114 eligible participants who have undergone cerclage were randomly divided to either receive probiotic adjuvant or 17α-OHP (250 mg, IM) with placebo from the 16th -37th week of pregnancy by “block” randomization method. Our primary outcomes were preterm labor (PTB) (late and early) and secondary outcomes were other obstetrical and neonatal outcomes included preterm pre-labor rupture of membranes (PPROM), pre-labor rupture of membranes (PROM), mode of delivery, and neonatal outcomes including anthropometric characterize and Apgar score (one and fifth-minute).
Results
Results show that there are no statistically significant differences between the two groups in terms of PTB in < 34th (15.51% vs. 17.86%;
P
= 0.73) and 34-37th weeks of pregnancy (8.7% vs. 16.1%;
P
= 0.22), and mode of delivery (
P
= 0.09). PPROM (8.7% vs. 28.5%;
P
= 0.006) PROM (10.3% vs. 25%;
P
= 0.04) was significantly lower in patients receiving probiotic adjuvant compared to the control group. After delivery, the findings of the present study showed that there were no significant differences in newborn’s weight (3082.46 ± 521.8vs. 2983.89 ± 623.89), head circumstance (36.86 ± 1.53vs. 36.574 ± 1.52), height (45.4 ± 5.34 vs. 47.33 ± 4.92) and Apgar score in one (0.89 ± 0.03 vs. 0.88 ± 0.05) and five minutes (0.99 ± 0.03vs. 0.99 ± 0.03) after birth.
Conclusion
Our result has shown that the consumption of Lactofem probiotic from the 16th week until 37th of pregnancy can lead to a reduction of complications such as PPROM and PROM.
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
/ Adult
/ Cerclage
/ Cerclage, Cervical - methods
/ Cervix
/ Female
/ Fetal Membranes, Premature Rupture
/ Humans
/ Iran
/ Medicine
/ Obstetric Labor, Premature - prevention & control
/ Premature Birth - prevention & control
/ Probiotics - administration & dosage
/ Probiotics - therapeutic use
/ Vagina
