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Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares

by Langley, Richard G. , Gordon, Kenneth , Tsoi, Lam C. , Sarkar, Mrinal K. , Mostaghimi, Arash , Tang, Ming , Warren, Richard B. , Cole, Christopher , Burden, A. David , Barker, Jonathan N. , Zheng, Min , Bogle, Rachael , Thoma, Christian , Coon, Anthony , Strober, Bruce , Merola, Joseph F. , Delic, Denis , Becker, Kolja , Mangold, Aaron R. , Anadkat, Milan J. , Lebwohl, Mark G. , Morita, Akimichi , Krueger, James G. , Gudjonsson, Johann E.

in Antibodies, Monoclonal, Humanized / Cytokine receptors / Dermatology / Drug therapy / Female / Health aspects / Humans / Inflammation / Inflammation - drug therapy / Inflammation - pathology / Male / Middle Aged / Physiological aspects / Psoriasis / Psoriasis - drug therapy / Psoriasis - metabolism / Psoriasis - pathology / Receptors, Interleukin - antagonists & inhibitors / Receptors, Interleukin - immunology / Research Letter

2025

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Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares

2025

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Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares

2025

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Journal Article

Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares

Langley, Richard G.,

Gordon, Kenneth,

Tsoi, Lam C.,

Sarkar, Mrinal K.,

Mostaghimi, Arash,

Tang, Ming,

Warren, Richard B.,

Cole, Christopher,

Burden, A. David,

Barker, Jonathan N.,

Zheng, Min,

Bogle, Rachael,

Thoma, Christian,

Coon, Anthony,

Strober, Bruce,

Merola, Joseph F.,

Delic, Denis,

Becker, Kolja,

Mangold, Aaron R.,

Anadkat, Milan J.,

Lebwohl, Mark G.,

Morita, Akimichi,

Krueger, James G.,

Gudjonsson, Johann E.

2025

Overview

People with generalized pustular psoriasis experience underlying skin inflammation, even in the absence of flares. Spesolimab treatment helps control the inflammation and prevent future flares.People with generalized pustular psoriasis experience underlying skin inflammation, even in the absence of flares. Spesolimab treatment helps control the inflammation and prevent future flares.

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Publisher

American Society for Clinical Investigation

Subject

Antibodies, Monoclonal, Humanized

/ Female

/ Humans